Publications by authors named "J R Korzenik"
Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with a strong association with inflammatory bowel disease and variable disease progression. We aimed to gain insights into the role of fecal bile acids (BA) on disease progression by determining the relationships between fecal BA, diet, and gut microbes, with markers of disease progression, BA synthesis, and farnesoid X receptor (FXR) activity.
Methods: BA levels in serum and stool, dietary intake, and markers of BA synthesis, and FXR activity were measured in 26 patients with early stage, large duct PSC.
Background: Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by inflammation and progressive fibrosis of the biliary tree. The pathogenesis of PSC remains poorly understood, and there are no effective therapeutic options. Previous studies have observed associations between changes in the colonic and biliary microbiome and PSC.
View Article and Find Full Text PDFPerformance of bowel preparation quality scales in patients with Crohn's disease.
Aliment Pharmacol Ther
October 2024
Article Synopsis
- The study aimed to evaluate various instruments for assessing bowel preparation (BP) quality in patients with Crohn's disease, a condition where BP performance is not well understood.!
- Five different scales were used to analyze BP quality in videos from 40 patients, focusing on reliability and validity through statistical methods.!
- Results showed that most instruments demonstrated substantial reliability, with a negative correlation between BP quality and disease activity scores, indicating these tools are useful in clinical practice and research for Crohn's disease patients.!
Background: Comparisons among autoimmune diseases enable understanding of the burden and factors associated with work productivity loss and impairment.
Aims: The objective was to compare work productivity and activity and associated factors among patients with inflammatory bowel diseases and other autoimmune conditions.
Methods: This cross-sectional study included employed, adult patients (age 20-64 years) in the CorEvitas Inflammatory Bowel Disease, Psoriasis, and Psoriatic Arthritis/Spondyloarthritis Registries between 5/2017 and 6/2020.