Publications by authors named "J R Korn"
Article Synopsis
- Changes in DNA methylation patterns contribute significantly to the aging process in human skin, affecting gene expression and skin functionality.
- Researchers screened a large library of substances and found that dihydromyricetin (DHM), a natural antioxidant, effectively inhibits the DNA methyltransferase DNMT1, which is involved in maintaining these patterns.
- Treatment with DHM resulted in noticeable changes in DNA methylation, leading to a reduction in biological age and improvements in gene activation and skin thickness in experimental models.
Unlabelled: Although androgen deprivation treatment often effectively decreases prostate cancer, incurable metastatic castration-resistant prostate cancer (CRPC) eventually occurs. It is important to understand how CRPC metastasis progresses, which is not clearly defined. The loss of PTEN, a phosphatase to dephosphorylate phosphatidylinositol 3,4,5-trisphosphate in the PI3K pathway, occurs in up to 70% to 80% of CRPC.
View Article and Find Full Text PDFUnlabelled: For a majority of patients with non-small cell lung cancer with EGFR mutations, treatment with EGFR inhibitors (EGFRi) induces a clinical response. Despite this initial reduction in tumor size, residual disease persists that leads to disease relapse. Elucidating the preexisting biological differences between sensitive cells and surviving drug-tolerant persister cells and deciphering how drug-tolerant cells evolve in response to treatment could help identify strategies to improve the efficacy of EGFRi.
View Article and Find Full Text PDFRadon-222 (Rn) and its decay products are the primary sources of a population's exposure to background ionizing radiation. Radon decay products are the leading cause of lung cancer for non-smokers and the second leading cause of lung cancer after smoking for smokers. A community-driven long-term radon survey was completed in 232 residential homes in different subdivisions of Whitehorse, the capital of the Yukon, during the heating season from November to April in 2016-2017 and in 2017-2018.
View Article and Find Full Text PDFBackground: Somatic alterations in the cancer genome, some of which are associated with changes in gene expression, have been characterized in multiple studies across diverse cancer types. However, less is known about germline variants that influence tumor biology by shaping the cancer transcriptome.
Methods: We performed expression quantitative trait loci (eQTL) analyses using multi-dimensional data from The Cancer Genome Atlas to explore the role of germline variation in mediating the cancer transcriptome.