Publications by authors named "J R Keyes"
Article Synopsis
- * In addition to its effects on glucose metabolism, insulin affects reproductive health by suppressing the secretion of gonadotropins from the pituitary gland, particularly in states of high insulin levels (hyperinsulinemia).
- * Research using LβT2 gonadotropic cells reveals that insulin stimulation leads to the unexpected movement of GLUT1 transporters to the cell membrane, occurring independently of the typical Akt signaling pathway, suggesting a complex role for insulin in these cells.
Background And Objective: There is limited research on screening for social determinants of health (SDOH) in hospitalized pediatric patients. In this article, we describe patient characteristics related to SDOH screening in the hospital setting and examine relationships with acute care metrics.
Methods: This is a retrospective cohort study.
Article Synopsis
- Around 158,500 people in the U.S. have undiagnosed HIV, which complicates treatment and health outcomes, especially for those on immunosuppressive therapy.
- Patients taking these therapies are at heightened risk for infections, yet routine HIV testing before treatment isn't standard practice.
- A case study of three patients shows that undiagnosed HIV led to severe complications during their course of immunosuppressive treatment, highlighting the need for pre-treatment HIV screening.
Background: The effect of contact force (CF) on lesion formation is not clear during pulsed field ablation (PFA). The aim of this study was to evaluate the impact of CF, PFA, and their interplay through the PFA index (PF index) formula on the ventricular lesion size in swine.
Methods: PFA was delivered through the CF-sensing OMNYPULSE catheter.
Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are dysregulated in many pervasive diseases. Recently, we discovered that ERK1/2 is oxidized by signal-generated hydrogen peroxide in various cell types. Since the putative sites of oxidation lie within or near ERK1/2's ligand-binding surfaces, we investigated how oxidation of ERK2 regulates interactions with the model substrates Sub-D and Sub-F.
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