Plasmapheresis in Sepsis-induced Thrombotic Microangiopathy: A Case Series.

Introduction: Cytokines and granulocyte elastase produced in sepsis cleave a disintegrin and metalloprotease with thrombospondin type I motif 13 (ADAMTS13) and deplete its levels. By this mechanism, sepsis results in microangiopathic hemolytic anemia (MAHA) with thrombocytopenia. Hence, the hypothesis is that plasmapheresis may help in sepsis-induced thrombotic microangiopathy (sTMA), by removing the factors responsible for low levels of ADAMTS13.

Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics.

Cancer remained a major cause of death providing diversified challenges in terms of treatment including non-specific toxicity, chemoresistance and relapse. Nanotechnology- based delivery systems grabbed tremendous attention for delivering cancer therapeutics as they provide benefits including controlled drug release, improved biological half-life, reduced toxicity and targeted delivery. Majority of the nanocarriers consists of either a polymer or a lipid component along with other excipients to stabilize the colloidal system.

Highly Sensitive Detection of Arsenite Based on Its Affinity toward Ruthenium Nanoparticles Decorated on Glassy Carbon Electrode.

Metallic ruthenium nanoparticles (Ru NPs) are formed on the glassy carbon electrode (GC) at electrodeposition potential of -0.75 V, as observed from X-ray photoelectron spectroscopy. Thus formed Ru NPs have the arsenite selective surface and conducting core that is ideally suited for designing a highly sensitive and reproducible response generating matrix for the arsenite detection at an ultratrace concentration in aqueous matrices.

Scope of detection and determination of gallium(III) in industrial ground water by square wave anodic stripping voltammetry on bismuth film electrode.

Gallium(III) in ground water may cause human health hazards due to the antineoplastic and antimicrobial activities of gallium. However, the exposure limit of Ga(III) has not been set. This paper demonstrates the scope of employing the square wave anodic stripping voltammetry (SWASV) on bismuth film electrode (BiFE) for selective and sensitive detection of Ga(III) as well as its accurate and precise determination.

Antioxidant activity and free radical scavenging reactions of hydroxybenzyl alcohols. Biochemical and pulse radiolysis studies.

Comparative studies on free radical scavenging by isomers of hydroxybenzyl alcohols (HBAs) were carried out to understand the molecular mechanisms involved in the antioxidant action. Using rat liver mitochondria as model systems, we have examined the radioprotective and antioxidant effects of hydroxybenzyl alcohols. Apart from their ability to scavenge free radicals and ferric reducing power, HBAs have shown good protection against radiation and oxidative stress.