Fabrication of highly biocompatible SiO@Au-BSA nanoconjugates: Towards a promising thermal therapy route.

SiO@Au nanoshells have gained relevance in recent years, especially in biomedical areas, acting as thermal therapy agents due to their high capacity to absorb light and transform it into heat that increases the temperature of the medium. Therefore, it is important to develop methodological strategies to obtain stable, highly specific and biocompatible nanoparticles. In this work, the synthesis of core-shell structures based on SiO@Au is reported, where the growth a thin shell ⁓ 46 nm on silica platform was possible.

Randomized Controlled Trial to Assess the Feasibility of a Novel Clinical Decision Support System Based on the Automatic Generation of Alerts through Remote Patient Monitoring.

: Early identification of complications in chronic and infectious diseases can reduce clinical deterioration, lead to early therapeutic interventions and lower morbidity and mortality rates. Here, we aimed to assess the feasibility of a novel clinical decision support system (CDSS) based on the automatic generation of alerts through remote patient monitoring and to identify the patient profile associated with the likelihood of severe medical alerts. : A prospective, multicenter, open-label, randomized controlled trial was conducted.

Electrophilic Hydrosilylation of Electron-Rich Alkenes Derived from Enamines.

The low-electron count, air-stable, platinum complexes [Pt(IBu')(IBu)][BAr] (C1) (IBu=1,3-di-tert-butylimidazol-2-ylidene), [Pt(SiPh)(IBuPr)][BAr] (C2) (IBuPr=1-tert-butyl-3-iso-propylimidazol-2-ylidene), [Pt(SiPh)(IBuMe)][BAr] (C3), [Pt(GePh)(IBuPr)][BAr] (C4), [Pt(GePh)(IBuMe)][BAr] (C5) and [Pt(GeEt)(IBuMe)][BAr] (C6) (IBuMe=1-tert-butyl-3-methylimidazol-2-ylidene) are efficient catalysts (particularly the germyl derivatives) in both the silylative dehydrocoupling and hydrosilylation of electron rich alkenes derived from enamines. The steric hindrance exerted by the NHC ligand plays an important role in the selectivity of the reaction. Thus, bulky ligands are selective towards the silylative dehydrocoupling process whereas less sterically hindered promote the selective hydrosilylation reaction.

Human femur fracture by mechanical compression: Towards the repeatability of bone fracture acquisition.

The increase in life expectancy combined with greater bone fragility over the years is causing a rise in the bone fracture cases. Femur fractures are the most important due to their high mortality rate. This multidisciplinary work is carried out in this context and focuses on the experimental reproduction of human femur fractures by compression.

Hybrid curvature-geometrical detection of landmarks for the automatic analysis of the reduction of supracondylar fractures of the femur.

Background And Objective: The analysis of the features of certain tissues is required by many procedures of modern medicine, allowing the development of more efficient treatments. The recognition of landmarks allows the planning of orthopedic and trauma surgical procedures, such as the design of prostheses or the treatment of fractures. Formerly, their detection has been carried out by hand, making the workflow inaccurate and tedious.