Publications by authors named "J R Izbicki"
Background: The lack of predictive biomarkers contributes notably to the poor outcomes of patients with pancreatic ductal adenocarcinoma (PDAC). Cancer-associated fibroblasts (CAFs) are the key components of the prominent PDAC stroma. Data on clinical relevance of CAFs entering the bloodstream, known as circulating CAFs (cCAFs) are scarce.
View Article and Find Full Text PDFObjective: The aim was to evaluate the sustainability of the pancreatic Enhanced Recovery After Surgery (ERAS) program and the effect of ERAS items on patient morbidity and hospital stay.
Background: The current ERAS guideline recommendations encompass 27 items to improve recovery after pancreatoduodenectomy (PD).
Methods: Patients who underwent pancreatic resection at the University Hospital Hamburg-Eppendorf between February 2016 and June 2023 were included.
Objective: To describe the evolution of management strategies for neuroendocrine liver metastases (NE LM) and trends in patient outcomes over the preceding 3 decades.
Summary Background Data: Liver metastases are common in neuroendocrine neoplasms and impair prognosis. A broad therapeutic armamentarium has evolved over recent decades but there remains uncertainty regarding optimal treatment selection and sequencing.
Article Synopsis
- International guidelines for imaging follow-up after pancreatic resection for pancreatic ductal adenocarcinoma (PDAC) are inconsistent, leading to varied follow-up strategies globally.
- The study aimed to compare clinical outcomes, including treatment for recurrence and survival rates, between patients who received either symptomatic follow-up or routine imaging after PDAC surgery across 33 international centers.
- A total of 333 patients were analyzed, showing that 29% had symptomatic follow-up while 71% underwent routine imaging, with overall survival rates being examined through statistical methods to identify the impact of the follow-up strategy on patient outcomes.
Objective: To validate the ISGPS definition and grading system of PPAP after pancreatoduodenectomy (PD).
Summary Background Data: In 2022, the International Study Group for Pancreatic Surgery (ISGPS) defined post-pancreatectomy acute pancreatitis (PPAP) and recommended a prospective validation of its diagnostic criteria and grading system.
Methods: This was a prospective, international, multicenter study including patients undergoing PD at 17 referral pancreatic centers across Europe, Asia, Oceania, and the United States.