Publications by authors named "J R Iredell"
Article Synopsis
- Rising rates of antimicrobial resistance (AMR) were noted in Staphylococcus aureus and Enterococcus spp. in Australia, with a significant number of blood stream infections (BSIs) occurring in children.
- The Australian Group on Antimicrobial Resistance (AGAR) analyzed 2,091 S. aureus and 534 enterococcal BSIs over nine years, revealing key trends in community vs. hospital onset infections and varying resistance levels.
- A shift in resistance profiles was observed, especially in Enterococcus faecium, prompting the need for detailed and age-stratified reporting of AMR data.
Background: Gram-negative bloodstream infections are associated with significant morbidity and mortality in children. Increasing antimicrobial resistance (AMR) is reported globally, yet efforts to track pediatric AMR at a national level over time are lacking.
Methods: The Australian Group on Antimicrobial Resistance (AGAR) surveillance program captures clinical and microbiological data of isolates detected in blood cultures across Australia.
From 1 January 2020 to 31 December 2021, thirty-eight institutions across Australia submitted data to the Australian Group on Antimicrobial Resistance (AGAR) from patients aged < 18 years (AGAR-Kids). Over the two years, 1,679 isolates were reported from 1,611 patients. This AGAR-Kids report aims to describe the population of children and adolescents with bacteraemia reported to AGAR and the proportion of resistant isolates.
View Article and Find Full Text PDFIntroduction: Pseudomonas aeruginosa is an organism well known for causing significant morbidity and mortality in people living with chronic lung conditions such as cystic fibrosis. We describe the safety, tolerability, and potential efficacy of bronchoscopic and nebulised bacteriophage administration, offering insights into a potential breakthrough for the treatment of chronic infections particularly in children and adolescents.
Method: A 12-year-old female (F12) and a 17-year-old male (M17), both diagnosed with cystic fibrosis and chronic P.
Article Synopsis
- This study investigates the clinical characteristics and outcomes of sepsis patients based on the results of their blood and urine cultures, focusing on identifying factors leading to positive cultures.
- Among 4109 sepsis patient encounters in Australia, a variety of culture results were noted, with nonbacteremic urine culture-negative patients showing the highest prevalence and bacteremic patients encountering worse clinical outcomes, particularly in ICU admissions and hospital stays.
- The findings emphasize the importance of timely culture sample collection prior to antibiotic treatment to improve patient outcomes, especially for those with nongenitourinary infections.