Publications by authors named "J R Holt"
The inner ear houses both hearing and balance sensory modalities. The hearing and balance organs consist of similar cell types, including sensory hair cells and associated supporting cells. Previously we showed that is required for maintaining supporting cell survival during cochlear maturation.
View Article and Find Full Text PDFCalcium and integrin-binding protein 2 (CIB2) and CIB3 bind to transmembrane channel-like 1 (TMC1) and TMC2, the pore-forming subunits of the inner-ear mechano-electrical transduction (MET) apparatus. These interactions have been proposed to be functionally relevant across mechanosensory organs and vertebrate species. Here, we show that both CIB2 and CIB3 can form heteromeric complexes with TMC1 and TMC2 and are integral for MET function in mouse cochlea and vestibular end organs as well as in zebrafish inner ear and lateral line.
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- The study addresses the challenges of creating precise models for the nuclear force and managing uncertainties in quantum many-body calculations, which are crucial for understanding nuclei and nuclear matter.
- Researchers use generative machine learning to develop new nucleon-nucleon interaction instances by training on existing potential data from literature.
- The generative model successfully creates nucleon-nucleon potentials that yield high-quality scattering phase shifts, aiding in better estimation of theoretical uncertainties in nuclear calculations related to different nuclear interactions and resolution scales.
Pharmacogenomics is central to precision medicine, informing medication safety and efficacy. Pharmacogenomic diplotyping of complex genes requires full-length DNA sequences and detection of structural rearrangements. We introduce StarPhase, a tool that leverages PacBio HiFi sequence data to diplotype 21 CPIC Level A pharmacogenes and provides detailed haplotypes and supporting visualizations for , , and .
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- Trust is complex with various definitions and measurement scales, making it hard to compare studies and choose the right instruments.
- Multiple studies identified six distinct factors of trust and narrowed them down to four key categories: confidence in others, belief in others' reliability, belief in others' honesty, and beliefs about others' trustworthiness.
- The findings indicate that these four factors largely operate independently of demographics like sex and political stance and are linked to the personality trait of agreeableness, while also influencing decisions like acceptance of water recycling beyond basic biases.