Publications by authors named "J R Hassell"
In 2024, there have been increases in laboratory confirmed infections of Mycoplasma Pneumoniae infection worldwide. This case series highlights increasing frequency of Mycoplasma pneumoniae positive PCR specimens and an increased number of hospital admissions with Mycoplasma pneumoniae clinical syndromes. Within this case series, we observed, a change in the epidemiology and clinical burden of childhood Mycoplasma pneumonia disease in the post COVID-19 era.
View Article and Find Full Text PDFRabies vaccination in domestic dog populations has increased globally in a bid to protect human health. Surveillance efforts, however, are inconsistent in endemic regions such as in sub-Saharan Africa, due to fragmented reporting and limited diagnostic capacity for suspected cases, limiting successful monitoring and evaluation of vaccination campaigns. Here, we conducted a pilot study aiming to strengthen rabies surveillance by combining community-based surveillance with field-based diagnostic testing in pastoral and agro-pastoral communities in central Kenya; communities which are frequently marginalised from health systems.
View Article and Find Full Text PDFBackground And Objectives: Disorders of coenzyme Q (CoQ) biosynthesis comprise a group of 11 clinically and genetically heterogeneous rare primary mitochondrial diseases. We sought to delineate clinical, biochemical, and neuroimaging features of these disorders, together with outcomes after oral CoQ supplementation and the utility of peripheral blood mononuclear cell (PBMNC) CoQ levels in monitoring therapy.
Methods: This was a retrospective cohort study, registered as an audit at a specialist pediatric hospital (Registration Number: 3318) of 14 patients with genetically confirmed CoQ biosynthesis deficiency, including 13 previously unreported cases.
Article Synopsis
- HSV-1 primarily infects the oral and nasal areas before establishing latency in the trigeminal ganglion and can also infect the central nervous system (CNS) via specific pathways.
- Recent studies have highlighted the lack of detailed knowledge about which brain regions are affected during HSV-1 infections and how microglial responses differ across these regions.
- This study on a mouse model revealed a two-step spread of HSV-1 from the olfactory epithelium to select brain regions, along with varying activation levels of microglia, contributing to understanding HSV-1's role in neurological diseases.
Article Synopsis
- HSV-1 primarily infects the oral and nasal areas before becoming latent in the trigeminal ganglia and can also infect the central nervous system (CNS) through specific pathways.
- The study used a mouse model to observe how HSV-1 spreads through the olfactory epithelium and CNS, finding a distinct spread pattern and accompanying inflammatory response from immune cells.
- The research identified specific brain regions affected by HSV-1, revealing no involvement of the hippocampus or cortex, and highlighted varied microglial activation across different regions, suggesting implications for neurological diseases.