Publications by authors named "J R Handforth"
Article Synopsis
- PIMS-TS is a serious immune disorder linked to COVID-19 in children, with a focus on neurologic symptoms noted in 12% of patients.
- The study reviewed 75 cases, finding various neurologic issues such as altered consciousness, behavioral changes, and seizures, with some patients showing abnormalities in brain imaging.
- By three months post-presentation, half of the children with neurologic symptoms had fully recovered, while higher systemic inflammatory markers were noted in those with neurologic involvement and those not fully recovered.
Article Synopsis
- * The study examined 70 children admitted to Evelina London Children's Hospital during a specific period, highlighting the link between ethnicity, socioeconomic status, and the severity of PIMS-TS.
- * Findings revealed that children from deprived areas and key worker families experienced longer hospital stays, with black children having notably higher admission durations and ventilation needs.
This article describes the rapid, system-wide reconfiguration of local and network services in response to the newly described paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) (also known as multisystem inflammatory syndrome in children). Developing the model of care for this novel disease, whose natural history, characteristics and treatment options were still unclear, presented distinct challenges.We analyse this redesign through the lens of healthcare management science, and outline transferable principles which may be of specific and urgent relevance for paediatricians yet to experience the full impact of the COVID-19 pandemic; and more generally, for those developing a new clinical service or healthcare operating model to manage the sudden emergence of any unanticipated clinical entity.
View Article and Find Full Text PDFBackground: To date, although neonatal infections with severe acute respiratory syndrome coronovirus 2 (SARS-CoV-2) have been described, none of these have been proven to be the result of vertical transmission of SARS-CoV-2.
Methods: We describe the probable vertical transmission of SARS-CoV-2 in a neonate born to a mother with coronavirus disease 2019 (COVID-19).
Results: Following cesarean section, the neonate was kept in strict isolation.