Publications by authors named "J R Hadley"
Aims/hypothesis: Upregulation of serum leucine-rich α-2-glycoprotein 1 (LRG1) has been implicated in diet-induced obesity and metabolic disorders. However, its specific hormonal actions remain unclear. This study aimed to determine whether diet-enhanced serum LRG1 levels promote hyperinsulinaemia by directly stimulating insulin secretion from pancreatic beta cells.
View Article and Find Full Text PDFCancer mutations can create neomorphic protein-protein interactions to drive aberrant function . As a substrate receptor of the CULLIN3-RBX1 E3 ubiquitin ligase complex, KBTBD4 is recurrently mutated in medulloblastoma (MB) , the most common embryonal brain tumor in children, and pineoblastoma . These mutations impart gain-of-function to KBTBD4 to induce aberrant degradation of the transcriptional corepressor CoREST .
View Article and Find Full Text PDFPurpose: To validate single reference variable flip angle (SR-VFA) dynamic T mapping with and without T * correction against inversion recovery (IR) T measurements.
Methods: A custom cylindrical phantom with three concentric compartments was filled with variably doped agar to produce a smooth spatial gradient of the T relaxation rate as a function of angle across each compartment. IR T , VFA T , and B measurements were made on the phantom before rotation, and multi-echo stack-of-radial dynamic images were acquired during rotation via an MRI-compatible motor.
Article Synopsis
- - This study focuses on identifying the cellular origins of common childhood brain tumors (ependymoma, pilocytic astrocytoma, and medulloblastoma) using a human cerebellar atlas, which offers a more accurate reference than previous methods that compared human tumors to mouse tissues.
- - Using a large dataset of normal and tumor-specific gene expressions, the researchers suggest that different brain tumors can arise from various progenitor cells in the cerebellum and have distinct lineage origins.
- - The findings indicate that tumors may consist of cells resembling different types from a specific developmental lineage, highlighting the complexity of tumor origins and suggesting potential therapeutic strategies based on identified tumor-specific genes.