Inflammation-related genes and the risk of Parkinson's disease: a multilocus approach.

For the first time, the multilocus approach by the set-association method has been applied for the analysis of a cluster of five genes [tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), IL-8, IL-1alpha and IL-10] involved in the brain neuroinflammatory pathway in Parkinson's disease (PD), in a well-defined group of 197 PD patients and 173 control subjects from Spain. Set-association analysis did not reveal an independent or an interactive effect of these inflammatory genes on the PD risk.

[Frequent users and difficult patients: how do they feel about their treatment by doctors?].

Background: To determine the opinions and expectations of difficult, frequent user, patients about their relationship with their GP.

Material And Methods: Qualitative design. Discussion groups.

[Clinico-epidemiological study of neurolisteriosis in the province of Segovia].

Introduction: Listeria monocytogenes is a microorganism with marked tropism towards the central nervous system. One of the commonest forms of presentation is as a meningeal infection. The objective of this study is to describe the epidemiological, clinical and laboratory characteristics and therapeutic implications.