Publications by authors named "J R Gregg"
Article Synopsis
- Oligometastatic prostate cancer (OMPCa) is an intermediate stage of cancer between localized and widespread disease, traditionally treated with androgen deprivation therapy (ADT) but now also considered for local therapies like cytoreductive prostatectomy (CRP) and radiotherapy.
- Recent studies suggest that CRP may be beneficial for some OMPCa patients, and ongoing trials are exploring its safety and effectiveness, alongside findings supporting the use of radiotherapy and ADT.
- There is still limited evidence for focal therapies and cryotherapy, highlighting the need for more clinical trials to better understand treatment options and suitability for patients with OMPCa.
Background: We previously reported that increases in circulating sphingolipids are associated with elevated risk of biopsy Gleason grade group (GG) upgrading in men on Active Surveillance (AS) for prostate cancer. Here, we aimed to validate these findings and establish a blood-based sphingolipid biomarker panel for identifying men on AS who are at high-risk of biopsy GG upgrading.
Methods: Men diagnosed with low- or intermediate-risk prostate cancer in one of two AS cohorts (CANARY PASS and MDACC) were followed for GG upgrading after diagnostic and confirmatory biopsy.
Crude oil toxicity to early life stage fish is commonly attributed to polycyclic aromatic hydrocarbons (PAHs). However, it remains unclear how the polar unresolved complex mixture (UCM), which constitutes the bulk of the water-soluble fraction of crude oil, contributes to crude oil toxicity. Additionally, the role of photomodification-induced toxicity in relation to the polar UCM is not well understood.
View Article and Find Full Text PDFHormone therapy (HT) to treat prostate cancer is reported to cause adverse changes in body composition. Clinically, interpatient body composition changes are heterogeneous, but the biological and clinical determinants of body composition toxicity are unknown. Herein, we test the hypothesis that inherited polymorphisms in steroidogenic genes are associated with differential changes in body composition after HT.
View Article and Find Full Text PDFArticle Synopsis
- The article reviews how effective whole-body magnetic resonance imaging (WBMRI) is for checking the spread of high-risk prostate cancer compared to other imaging methods.
- It found that WBMRI is just as good or better than CT scans for spotting cancer in lymph nodes and better than bone scans for finding cancer in bones.
- However, when it comes to detecting metastasis, new methods like PSMA PET scans are even more effective than WBMRI, so more research on costs and combining these methods is needed.