Publications by authors named "J R Goldblum"
Article Synopsis
- - The study focused on 44 cases of epithelioid myxofibrosarcoma (eMFS), a rare and aggressive cancer variant, examining factors like morphologic structure and cancer grading, revealing that the majority displayed diffuse epithelioid characteristics and high FNCLCC grades.
- - Among the patients, mostly older adults with a higher incidence in males, local recurrence and metastasis were common; specifically, 10 out of 22 monitored patients developed metastases, typically to regional lymph nodes, regardless of tumor grade.
- - An interesting note is that some cases initially diagnosed as eMFS shared genetic mutations typically seen in other UV-driven cancers, suggesting possible misdiagnosis and the need for careful evaluation
In research, language ability has historically been measured using structured tasks in laboratory settings. In recent years, there has been a growing emphasis on the need to instead capture language ability in an individual's natural setting (i.e.
View Article and Find Full Text PDFNuclear DUX4 immunohistochemistry is a highly sensitive and specific marker for the presence of CIC::DUX4 fusion in CIC-rearranged sarcomas: a study of 48 molecularly confirmed cases.
Rodrigo T Macedo Vira Baranovska-Andrigo Tamás Pancsa Natálie Klubíčková Brian P Rubin John R Goldblum
Histopathology
October 2024
Article Synopsis
- CIC-rearranged sarcomas (CRS) are aggressive tumors often driven by a specific fusion gene (CIC::DUX4), which can be difficult to detect through molecular testing due to variability in the fusion breakpoints.* -
- The study evaluated the effectiveness of DUX4 immunohistochemistry (IHC) in identifying CRS by analyzing 48 confirmed CRS cases alongside 105 non-CRS cases across various types of tumors.* -
- DUX4 IHC showed a sensitivity of 98% and specificity of 100% for diagnosing CRS, making it a reliable marker to assist in detecting these tumors, despite one false negative case involving a different fusion.*
Article Synopsis
- - Significant advances in managing large laterally spreading tumors (LSTs) in colorectal polyps exist, but management practices vary globally, prompting the need for an international consensus.
- - A Delphi study involving 43 experts from 18 countries led to 42 statements reaching consensus regarding training, evaluation, resection techniques, and post-resection care for LSTs.
- - The resulting expert consensus aims to standardize practices and provide clear guidance for evaluating, resecting, and following up on LSTs worldwide.
Gastrointestinal (GI) tract involvement by Langerhans cell histiocytosis (LCH) is rare and its clinicopathologic characteristics have only been described in case reports and small series. We reviewed hematoxylin and eosin and CD1a, S100, and Langerin immunohistochemical-stained slides from 47 patients with well-documented demographic and clinical findings. Our cases included 8 children and 39 adults, with a mean follow-up of 63 months.
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