Publications by authors named "J R Gayen"
Withanone (WN), a bioactive phytochemical isolated from the medicinal herb Withania somnifera, has shown multiple pharmacological and therapeutic successes, including neuroprotective and anti-cancer activities. However, detailed pharmacokinetic (PK) properties of pure WN were not well defined. Pharmacokinetic (PK) characteristics, dose proportionality, and absolute bioavailability of pure WN were explored in rats using an efficient, reliable, and sensitive LC-MS/MS assay to address this gap.
View Article and Find Full Text PDFPolycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder associated with insulin resistance (IR) and hyperandrogenism. IR plays a crucial role in the etiology of PCOS. An insulin-sensitizing agent like metformin is most commonly used as an off-label drug for the treatment of PCOS.
View Article and Find Full Text PDFFormononetin (FNT) has limited application due to poor water solubility and substantial phase II metabolism. In the present study, we used phospholipid complex (PC) containing FNT and UDP-glucuronosyltransferase (UGT1A1) inhibitor piperine (PIP) to overcome FNT limitations. We characterized and compared both FNT-PC and FNT-PIP-PC complexes.
View Article and Find Full Text PDFArticle Synopsis
- NOD1 is a receptor in cells that detects specific bacterial signals, triggering inflammation and is also influenced by metabolic stress from ER disturbances.
- Under ER stress, liver cancer cells (HepG2) show a stronger inflammatory response to bacterial components, which disrupts lipid and glucose metabolism.
- The heightened inflammatory response depends on specific proteins and calcium levels, indicating that metabolic stress increases liver cells' sensitivity to bacterial inflammation, impacting their nutrient processing.
Article Synopsis
- Dopamine receptors are being targeted for treating neurological disorders like Parkinson's and Alzheimer's, with a focus on developing selective D5 receptor agonists.
- Researchers designed and tested forty new pyrimidine derivatives, finding four that act as selective partial agonists for the D5 receptor, with compound 5j showing the most promising activity.
- Compound 5j demonstrated stability and the ability to improve memory in mice without toxicity, suggesting it could be a viable therapeutic option for cognitive impairment.