Publications by authors named "J R Earl"
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses of all common solid cancers. For the large majority of PDAC patients, only systemic therapies with very limited efficacy are indicated. In addition, immunotherapies have not brought the advances seen in other cancer types.
View Article and Find Full Text PDFBackground: Pancreatic ductal adenocarcinoma (PDAC) is associated with a significant percentage of germline pathogenic variants (GPVs). Unlike in the United States, routine universal genetic testing is not performed in Europe. The aim of the study is to evaluate the diagnostic yield of germline genetic testing in all patients with PDAC.
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- The study examines how single-nucleotide polymorphisms (SNPs) in enzyme-coding genes impact the effectiveness and side effects of chemotherapy in colorectal cancer patients receiving fluoropyrimidine-based treatments.!* -
- It involved analyzing enzyme activity to find correlations with treatment outcomes, drug toxicity, and hypersensitivity reactions in 51 patients.!* -
- The findings suggest that pharmacogenetics can be used as a predictive tool in oncology, aiding in understanding how patients respond to chemotherapy and their potential for experiencing side effects.!*
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) play an important role in the treatment of type 2 diabetes (T2D) and obesity. The relationship between efficacy and dosing regimen has been studied extensively for this class of molecules. However, a comprehensive analysis of the translation of in vitro data to in vivo efficacious exposure is still lacking.
View Article and Find Full Text PDFBackground And Aims: Timely and accurate detection of tumor recurrence in pancreatic ductal adenocarcinoma (PDAC) patients is an urgent and unmet medical need. This study aimed to develop a noninvasive molecular diagnostic procedure for the detection of recurrence after PDAC resection based on quantification of circulating mRNA and miRNA biomarkers in serum samples.
Methods: In a multicentric study, serum samples from a total of 146 patients were prospectively collected after resection.