Publications by authors named "J R Eagles"
Article Synopsis
- CREBBP and KMT2D are important genes that, when mutated together, can lead to more serious lymphomas in mice compared to when either gene is mutated alone.
- These mutations create an environment where T-cells, which are important for fighting off infections and cancer, become tired and fail to function properly.
- The study discovered that the mutations affect how the immune system interacts with lymphoma cells, showing that these gene changes work together to help cancer grow.
Article Synopsis
- People with Li-Fraumeni syndrome (LFS) have a near 100% chance of developing cancer due to a mutation in the TP53 gene and undergo regular cancer screening.
- A new liquid biopsy test combining various sequencing techniques was tested on 89 LFS patients, showing improved cancer detection rates compared to traditional methods.
- This integrated testing approach demonstrated earlier detection of cancer signals, highlighting its potential as a valuable tool in patient care, although further validation is needed before widespread use.
Immune checkpoint blockade (ICB) provides clinical benefit to a subset of patients with cancer. However, existing biomarkers do not reliably predict treatment response across diverse cancer types. Limited data exist to show how serial circulating tumor DNA (ctDNA) testing may perform as a predictive biomarker in patients receiving ICB.
View Article and Find Full Text PDFDuring the first three months of the Temple Vie programme, average weight loss in 36 subjects exceeded 13 kg. There were associated improvements in Patient Reported Outcome Measures, blood pressure and serum lipids. The Covid-19 pandemic may focus attention on programmes that give rise to rapid weight loss and improvements in cardiovascular health parameters.
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