Publications by authors named "J R DiPersio"
Article Synopsis
- Haploidentical hematopoietic cell transplantation (haplo-HCT) is being utilized more often for blood cancers, but complications such as graft vs. host disease (GvHD) still pose serious risks.
- A study tested the JAK-1 inhibitor itacitinib alongside standard GvHD preventive care in 42 patients and found it dramatically reduced the severity of complications like cytokine release syndrome (CRS) and instances of acute GvHD.
- Results showed high overall survival rates (80% at one year) and low rates of both acute and chronic GvHD, indicating that itacitinib is a promising addition to haplo-HCT treatment protocols.
Article Synopsis
- The text discusses the importance of effective time management for college students, outlining strategies to balance academic, work, and social life.
- It emphasizes the need for setting clear goals and priorities, recommending tools like planners and to-do lists to stay organized.
- Additionally, it highlights the benefits of self-care and regular breaks to maintain productivity and mental well-being during busy semesters.
Accurate assessment of therapy response in myelodysplastic neoplasm (MDS) has been challenging. Directly monitoring mutational disease burden may be useful, but is not currently included in MDS response criteria, and the correlation of mutational burden and traditional response endpoints is not completely understood. Here, we used genome-wide and targeted next-generation sequencing (NGS) to monitor clonal and subclonal molecular disease burden in 452 samples from 32 patients prospectively treated in a clinical trial.
View Article and Find Full Text PDFChimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematologic malignancies, offering remarkable remission rates in otherwise refractory conditions. However, its expansion into broader oncological applications faces significant hurdles, including limited efficacy in solid tumors, safety concerns related to toxicity, and logistical challenges in manufacturing and scalability. This review critically examines the latest advancements aimed at overcoming these obstacles, highlighting innovations in CAR T-cell engineering, novel antigen targeting strategies, and improvements in delivery and persistence within the tumor microenvironment.
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