Publications by authors named "J R Dembinski"
Article Synopsis
- * Postoperative PF occurred in 14.4% of patients, with the majority classified as grade B or C; however, the 5-year overall survival rate was slightly higher in the PF group (45.3%) compared to the non-PF group (37.0%), though not statistically significant.
- * In contrast, the 5-year recurrence-free survival was significantly better in patients with postoperative PF (43.7%) compared to those without it
In children with sickle cell disease (SCD), splenectomy is immediately beneficial for acute sequestration crises and hypersplenism (ASSC/HyS) but portends a long-term risk of asplenia-related complications. We retrieved peripheral and splenic red blood cells (RBCs) from 17 SCD children/teenagers undergoing partial splenectomy for ASSC/HyS, 12 adult subjects without RBC-related disease undergoing splenectomy (controls), five human spleens perfused ex vivo with Hb- and Hb-RBC, and quantified abnormal RBC by microscopy, spleen-mimetic RBC filtration, and adhesion assays. Spleens were analyzed by immunohistochemistry and transmission electron microscopy (TEM).
View Article and Find Full Text PDFBackground: Vaccination constitutes an attractive control measure for hepatitis E virus (HEV), a major cause of maternal and perinatal mortality globally. Analysis of pregnant participants in an effectiveness trial of the HEV vaccine HEV239 showed possible HEV239-associated fetal losses. We aimed to conduct a detailed analysis of this safety signal.
View Article and Find Full Text PDFSafety and effectiveness of a recombinant hepatitis E vaccine in women of childbearing age in rural Bangladesh: a phase 4, double-blind, cluster-randomised, controlled trial.
Lancet Glob Health
August 2024
Article Synopsis
- A study was conducted in Bangladesh to evaluate the safety and effectiveness of a recombinant hepatitis E vaccine (HEV239) in preventing hepatitis E during pregnancy, focusing on pregnant and non-pregnant women aged 16-39.
- The trial involved 67 villages and included over 19,000 participants who received either HEV239 or a control hepatitis B vaccine (Hepa-B), with follow-up for two years post-vaccination.
- Results showed no cases of hepatitis E among pregnant participants in either group, indicating HEV239's mild safety profile was comparable to Hepa-B, with no significant adverse events reported.
Article Synopsis
- The study investigates the impact of preoperative chemo(radio)therapy on patients with localized pancreatic adenocarcinoma, focusing on the rare occurrence of pathological complete response (pCR), where no cancer cells are found post-surgery.
- Conducted in 19 centers across 8 countries with 1758 participants, the research shows that only 4.8% of patients achieved pCR, which is linked to better overall survival rates compared to those who did not achieve pCR.
- Factors influencing the likelihood of pCR included the use of multiagent chemotherapy regimens other than the (m)FOLFIRINOX treatment, highlighting the need for tailored therapeutic approaches.