Total marrow irradiation as part of autologous stem cell transplantation for patients with multiple myeloma.

The efficacy and safety of total marrow irradiation (TMI) plus a reduced dose of melphalan as autologous stem cell transplantation (ASCT) preconditioning for multiple myeloma (MM) patients were evaluated. The 11 patients with MM had a median age of 57 (range: 46-75) years; six of them were at standard risk and five of them were at high risk based on the Mayo Stratification of Myeloma and Risk-adapted Therapy (mSMART) standard risk factors. Before ASCT, three patients achieved stringent complete response (sCR), two patients achieved complete remission (CR), and the rest of the patients had either partial response (PR) or progressive disease.

Lead-Grouped Multi-Stage Learning for Myocardial Infarction Localization.

The electrocardiogram (ECG) is a ubiquitous medical diagnostic tool employed to localize myocardial infarction (MI) that is characterized by abnormal waveform patterns on the ECG. MI is a serious cardiovascular disease, and accurate, timely diagnosis is crucial for preventing severe outcomes. Current ECG analysis methods mainly rely on intra- and inter-lead feature extraction, but most models overlook the medical knowledge relevant to disease diagnosis.

The nuclear factor-κ B inhibitor SN50 enhances the efficacy of B-cell maturation antigen-targeted chimeric antigen receptor T-cell therapy.

Not available.

Association between carotid ultrasound features and the detection of functionally significant coronary artery stenosis: a prospective study based on quantitative flow ratio.

Background: Carotid ultrasound is a helpful approach for classifying cardiovascular risk. Quantitative flow ratio (QFR) is used to evaluate functionally significant coronary artery stenosis (CAS). The aim of this prospective study was to investigate the correlation between carotid artery features from carotid ultrasound and functionally significant CAS.