Publications by authors named "J R Darling"
The adhesion of nanoparticles to lipid vesicles causes curvature deformations to the membrane to an extent determined by the competition between the adhesive interaction and the membrane's elasticity. These deformations can extend over length scales larger than the size of a nanoparticle, leading to an effective membrane-curvature-mediated interaction between nanoparticles. Nanoparticles with uniform surfaces tend to aggregate into unidimensionally close-packed clusters at moderate adhesion strengths and endocytose at high adhesion strengths.
View Article and Find Full Text PDFObjectives: Endovascular aneurysm repair (EVAR) for large infrarenal abdominal aortic aneurysms (AAA) has been associated with worse outcomes compared to EVAR for smaller AAAs. Whether these findings apply to complex AAAs (cAAA) remains uncertain.
Methods: We identified all intact complex EVAR (cEVAR) from 2012-2024 in the Vascular Quality Initiative.
Background: Ongoing innovations in the minimally invasive management of complex abdominal aortic aneurysms, including physician-modified endografts (PMEG) and, more recently, Fiber Optic RealShape (FORS) technology, have allowed vascular surgeons to expand the surgical indications for and complexity of care to this multifaceted patient population. Prior analyses have demonstrated intraoperative advantages of Fiber Optic RealShape in the management of complex abdominal aortic aneurysms for lower total procedural radiation and cannulation tasks; however, few analyses have evaluated the technology's effect on perioperative and postoperative outcomes.
Methods: All PMEGs performed at our institution between 2020 and 2024 were reviewed retrospectively.
Background: Oral malodor, whether from systemic disease, dietary sources, or bacteria in the oral cavity, can negatively impact patients' quality of life. Oral malodor due to bacteria in the oral cavity can be managed by mechanically or chemically removing bacteria. Dentifrices are ideal vehicles to deliver therapeutic active ingredients that promote and maintain oral health since most consumers brush their teeth daily.
View Article and Find Full Text PDFArticle Synopsis
- Cholangiocarcinoma is a bile duct cancer often diagnosed late, leading to poor prognosis, but selective FGFR inhibitors show promise in treating it, especially in cases with specific genetic alterations.
- These FGFR inhibitors can cause side effects like hyperphosphatemia, fatigue, and other gastrointestinal and dermatological issues, which need to be managed proactively to improve treatment adherence and patient outcomes.
- A multidisciplinary care team including various healthcare professionals is essential, with practical guidance provided on managing side effects, considering interactions with other medications or foods, and offering supportive care recommendations for patients.