Publications by authors named "J R Coles"
Contemporary therapies following heart failure center on regenerative approaches to account for the loss of cardiomyocytes and limited regenerative capacity of the adult heart. While the delivery of cardiac progenitor cells has been shown to improve cardiac function and repair following injury, recent evidence has suggested that their paracrine effects (or secretome) provides a significant contribution towards modulating regeneration, rather than the progenitor cells intrinsically. The direct delivery of secretory biomolecules, however, remains a challenge due to their lack of stability and tissue retention, limiting their prolonged therapeutic efficacy.
View Article and Find Full Text PDFDespite research supporting the efficacy of Automated Writing Evaluation (AWE) in improving writing outcomes, inconsistent implementation by teachers raises concerns about the efficacy of these systems in practice. However, little is known about what factors influence teachers' implementation and perceptions of AWE. This study examined the relationship between teachers' implementation and perceptions of the MI Write AWE system, seeking to identify actionable factors that could enhance AWE implementation and acceptance in the future.
View Article and Find Full Text PDFRare genetic respiratory disease has an incidence rate of more than 1:2500 live births in Northern Europe and carries significant disease burden. Early diagnosis improves outcomes, but many individuals remain without a confident genetic diagnosis. Improved and expanded molecular testing methods are required to improve genetic diagnosis rates and thereby improve clinical outcomes.
View Article and Find Full Text PDFArticle Synopsis
- A chronic subdural haematoma (cSDH) is an increasingly common condition in older adults, characterized by a collection of fluid and blood in the subdural space, with no existing guidelines for optimal care from symptom onset to recovery.
- This paper outlines the creation of consensus-based recommendations for the management of cSDH, developed by a multidisciplinary committee that included healthcare professionals, patients, and caregivers.
- The final guideline features 67 recommendations spread across eight themes, addressing key aspects such as diagnosis, surgical procedures, non-operative management, and post-operative care despite a general lack of high-quality evidence in the literature.
Article Synopsis
- * Through online focus groups with social workers from various U.S. transplant centers, the research explored caregiver requirements, challenges faced by patients and caregivers, and any flexibility in these requirements.
- * The findings revealed inconsistencies in caregiver requirements between transplant centers, which could create barriers to accessing treatment, emphasizing the need for further research to refine requirements and improve patient support.