Publications by authors named "J R Clayton"
Article Synopsis
- The article emphasizes the NIH's efforts to enhance women's health through innovative policies and research, expanding beyond reproductive health to encompass all aspects of women's health.
- The NIH has identified unique ways that diseases affect women due to biological and social factors, leading to significant scientific advances, but noted that access to these advancements is still a challenge for many women.
- Recent initiatives aim to bridge these gaps by promoting integrative women's health research, ultimately benefiting the health of women across all stages of life.
Enhanced Advance care planning and life Review Longitudinal Intervention (EARLI): Protocol for a cluster randomized controlled cross-over trial of life story work and facilitated advance care planning among older Australian adults in community settings.
Contemp Clin Trials
December 2024
Article Synopsis
- Advance care planning (ACP) is crucial for older adults but is not widely adopted in community aged care settings; recent studies suggest that holistic, person-centered approaches may enhance engagement.
- The EARLI trial is a randomized study involving 12 aged care organizations in Australia, aiming to test a combined life story work and facilitated ACP intervention over two years with participants aged 65 and older.
- By assessing outcomes like ACP engagement, documentation, and emotional well-being, the trial seeks to demonstrate that personalized approaches can improve ACP uptake and ultimately benefit older adults and their families.
Article Synopsis
- The JBJS symposium focused on the importance of including sex and gender in orthopaedic research to enhance study methods and patient outcomes, addressing current shortcomings in reporting.
- Barriers to proper reporting stem from cultural resistance, inadequate education on terminology and study design, insufficient funding for larger studies, and the need for better understanding of how biological and social factors like gender and race interact in health research.
- To overcome these challenges, the development of best-practice statistical methods and ongoing education for all stakeholders in research is crucial, with existing guidelines like the SAGER providing a framework for improvement and support from academic institutions and funders being essential for meaningful progress.
Community engagement is increasingly considered a key component of intervention development, as it can leverage community members' knowledge, experiences, and insights to create a nuanced intervention which meets the needs, preferences, and realities of the population of interest. Community engagement exists along a spectrum from outreach to the community to partnership with community members and organizations, and all levels of community engagement can benefit from systematic documentation of community feedback and decision-making processes. This paper demonstrates how we utilized the "Framework for Reporting Adaptations and Modifications to Evidence-based Interventions" (FRAME; Wiltsey Stirman et al.
View Article and Find Full Text PDFImportance: For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect and safety of these protocols remains uncertain.
Objective: To determine whether decisions based on assessment of CRP or PCT safely results in a reduction in the duration of antibiotic therapy.
Design, Setting, And Participants: A multicenter, intervention-concealed randomized clinical trial, involving 2760 adults (≥18 years), in 41 UK National Health Service (NHS) intensive care units, requiring critical care within 24 hours of initiating intravenous antibiotics for suspected sepsis and likely to continue antibiotics for at least 72 hours.