System Dynamics Modeling of Caries Severity States in Long-Term Care.

Dental caries among long-term care (LTC) residents is a persistent and complex problem driven by social and structural factors. Systems thinking may be useful in considering novel approaches to reducing disease. This study aimed to develop a system dynamics model to simulate the progression of dentate older adults in LTC through caries severity states and estimate the effects of 3 intervention scenarios on the progression of caries: preventive topical fluoride (TF), arrest of caries with silver diamine fluoride (SDF), and a combination of TF and SDF.

Intraspecific encounters can lead to reduced range overlap.

Direct encounters, in which two or more individuals are physically close to one another, are a topic of increasing interest as more and better movement data become available. Recent progress, including the development of statistical tools for estimating robust measures of changes in animals' space use over time, facilitates opportunities to link direct encounters between individuals with the long-term consequences of those encounters. Working with movement data for coyotes (Canis latrans) and grizzly bears (Ursus arctos horribilis), we investigate whether close intraspecific encounters were associated with spatial shifts in the animals' range distributions, as might be expected if one or both of the individuals involved in an encounter were seeking to reduce or avoid conflict over space.

Time-Motion and Technical-Tactical Aspects of Glory World Series Matches in the Male Middle-Heavy-Weight Category.

Purpose: To characterize the time structure of K1 kickboxing matches of Glory World Series (Glory) and to determine potential differences between winners and losers.

Methods: Seventeen matches of Glory 2019 (17 first rounds, 13 second rounds, and 8 third rounds) were video-analyzed to quantify (1) the time expended in high- and low-intensity activity and pauses, (2) the number and pattern of attacks, and (3) the number of effective attacks. Fighters were professional male athletes (age 27.

Improved functions for nonlinear sequence comparison using SEEKR.

SEquence Evaluation through -mer Representation (SEEKR) is a method of sequence comparison that uses sequence substrings called -mers to quantify the nonlinear similarity between nucleic acid species. We describe the development of new functions within SEEKR that enable end-users to estimate values that ascribe statistical significance to SEEKR-derived similarities, as well as visualize different aspects of -mer similarity. We apply the new functions to identify chromatin-enriched lncRNAs that contain -like sequence features, and we demonstrate the utility of applying SEEKR on lncRNA fragments to identify potential RNA-protein interaction domains.