Publications by authors named "J R Caeiro"
Antifungal stewardship: the Latin American experience.
Antimicrob Steward Healthc Epidemiol
December 2023
Antifungal stewardship is a critical component of healthcare management that focuses on optimizing the use of antifungal medications to improve patient outcomes, minimize resistance, and reduce healthcare costs. In resource-limited settings, the prevalence of fungal infections remains a significant health concern, often exacerbated by factors such as compromised immune systems, inadequate diagnostic capabilities, and limited access to antifungal agents. This paper reviews the current state of antifungal stewardship practices in developing countries, addressing the unique socioeconomic and healthcare landscape.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates cellular immunity responses against SARS-CoV-2 among patients in Córdoba, Argentina, during two distinct waves of the pandemic that featured different viral variants and social behavior.
- Findings reveal a disruption in lymphocyte populations, specifically noting an increase in B cells and a decrease in CD3 T cells compared to healthy donors, with a more significant reduction in Tregs among severe cases.
- Results suggest a potential new biomarker, the CD8/CD8 index, for predicting disease progression, as it correlated with increased severity while also showing altered effector cytokine production in T cell populations.
Immunosuppressed patients, transplant recipients, and those with acute or chronic respiratory disease are at increased risk for invasive fungal infections in Argentina. Although the national public system guarantees universal access to health care for all citizens, little is known about the quality of available diagnostic and treatment armamentaria for invasive fungal infections in the country. Between June and August 2022, infectious disease clinicians from each of the 23 provinces and the Autonomous City of Buenos Aires were contacted to describe local access to fungal diagnostic tools and antifungal agents.
View Article and Find Full Text PDFIntra-articular (IA) administration of drugs for the treatment of diseases such as rheumatoid arthritis, osteoarthritis and psoriatic arthritis is a common strategy; however, the rapid clearance from the synovial fluid restricts their effectivity due to the limited retention time. Drug Delivery Systems (DDS) are currently being developed to increase their joint retention time. This study compares the biodistribution and retention time of a senolytic peptide (PEP), with potential application in osteoarthritis disease, and this senolytic peptide encapsulated in a DDS based on a lipid nanoemulsion (PEPNE) by using positron emission tomography (PET) imaging.
View Article and Find Full Text PDFDifferent cytokine and chemokine profiles in hospitalized patients with COVID-19 during the first and second outbreaks from Argentina show no association with clinical comorbidities.
Front Immunol
February 2023
Article Synopsis
- This study investigates the effects of cytokine storms in COVID-19 patients from Córdoba, Argentina, comparing data from the first two waves of the pandemic to understand links between demographics, comorbidities, and disease outcomes.
- Results showed that patients during the second wave were younger and had fewer comorbidities, with distinct cytokine and chemokine profiles, while pre-existing conditions did not significantly impact cytokine levels.
- The research identified specific inflammatory markers, such as IL-6 and C-reactive protein, that could help predict patient outcomes, particularly differentiating between mortality and recovery during the first wave of infections.