A randomized trial comparing the intraoperative durability of double-gloving with Biogel® surgical gloves to 3 comparators.

Objective: To determine and compare the intraoperative durability of 4 major surgical glove brands.

Design Setting And Participants: This study is a randomized open-label clinical trial in which surgical gloves from 4 manufacturers are randomized to 5 surgical subspecialty study groups: (1) orthopedic surgery, (2) neurosurgery, (3) colorectal surgery, (4) trauma or acute general surgery, and (5) cardiac and plastic surgeries. The study was divided into 10 periods, with a cross-over design, and was conducted at a tertiary care academic medical center.

Climate, demography, immunology, and virology combine to drive two decades of dengue virus dynamics in Cambodia.

The incidence of dengue virus disease has increased globally across the past half-century, with highest number of cases ever reported in 2019 and again in 2023. We analyzed climatological, epidemiological, and phylogenomic data to investigate drivers of two decades of dengue in Cambodia, an understudied endemic setting. Using epidemiological models fit to a 19-y dataset, we first demonstrate that climate-driven transmission alone is insufficient to explain three epidemics across the time series.

Synthesis and reduction of [(CHSiMe)Ln(μ-OR)] (Ln = La, Ce) complexes: structural effects of bridging alkoxides.

Alcoholysis of Cp'Ln (Ln = La, Ce; Cp' = CHSiMe) generate high-yielding (72-97%) bimetallic Ln complexes of [Cp'Ln(μ-OR)] [R = Et, Pr, or CH-4-Bu]. Single-crystal X-ray diffraction of these complexes reveal unexpected decreases in Ln⋯Ln distances, increasing Cp-Ln-Cp angles, and increasing intermolecular C⋯C contacts with bulkier bridging alkoxides, in line with structural control driven by significant dispersion forces. H NMR spectroscopy of [Cp'Ce(μ-OEt)] and [Cp'Ce(μ-OPr)] revealed significantly upfield resonances assigned as methylene and methine moieties of -43.

Barriers and Facilitators of Colorectal Cancer Screening During the COVID-19 Pandemic.

Background: COVID-19 introduced new barriers to health care including cancer screenings. This study evaluated the role of pandemic- and copay-related barriers to colonoscopy and the extent to which home-based testing methods were utilized.

Methods: A cross-sectional survey assessed colorectal cancer (CRC) attitudes and screening early in the COVID-19 pandemic.

The Smallest Infectious Substructure Encoding the Prion Strain Structural Determinant Revealed by Spontaneous Dissociation of Misfolded Prion Protein Assemblies.

It is commonly accepted that the prion replicative propensity and strain structural determinant (SSD) are encoded in the fold of PrP amyloid fibril assemblies. By exploring the quaternary structure dynamicity of several prion strains, we revealed that all mammalian prion assemblies exhibit the generic property of spontaneously generating two sets of discreet infectious tetrameric and dimeric species differing significantly by their specific infectivity. By using perturbation approaches such as dilution and ionic strength variation, we demonstrated that these two oligomeric species were highly dynamic and evolved differently in the presence of chaotropic agents.