AABBA Graph Kernel: Atom-Atom, Bond-Bond, and Bond-Atom Autocorrelations for Machine Learning.

Graphs are one of the most natural and powerful representations available for molecules; natural because they have an intuitive correspondence to skeletal formulas, the language used by chemists worldwide, and powerful, because they are highly expressive both globally (molecular topology) and locally (atom and bond properties). Graph kernels are used to transform molecular graphs into fixed-length vectors, which, based on their capacity of measuring similarity, can be used as fingerprints for machine learning (ML). To date, graph kernels have mostly focused on the atomic nodes of the graph.

Assessment of the time-dependent need for stay in a high dependency unit (HDU) after major surgery by using data from an anesthesia information management system.

Admittance to a high dependency unit (HDU) is expensive. Patients who receive surgical treatment with 'low anterior resection of the rectum' (LAR) or 'abdominoperineal resection of the rectum' (APR) at our hospital are routinely treated in an HDU the first 16-24 h of the postoperative (PO) period. The aim of this study was to describe the extent of HDU-specific interventions given.

The development of an audit technique to assess the quality of safety barrier management.

This paper describes the development of a management model to control barriers devised to prevent major hazard scenarios. Additionally, an audit technique is explained that assesses the quality of such a management system. The final purpose of the audit technique is to quantify those aspects of the management system that have a direct impact on the reliability and effectiveness of the barriers and, hence, the probability of the scenarios involved.

Electrophysiologic pacing of vocal cord abductors in bilateral recurrent laryngeal nerve paralysis.

We have reconfirmed our previous findings that controlled, reproducible, sustained, discrete vocal cord abduction can be achieved synchronously with respiration by electrophysiologic stimulation of the paralyzed posterior cricoarytenoid muscles. Moreover, we have demonstrated that this can be triggered synchronously by employing the normal physiologic chest wall movements that occur on respiration. To our knowledge, this represents the first report of functionally paced vocal fold abduction with respiration employing physiologic chest wall motions using an implantable device, and may represent an important step in the development of a physiologic approach to bilateral recurrent laryngeal nerve paralysis.