Respiratory Ill-Health and Welding Exposures: A Canadian Cohort Study.

Introduction: Respiratory ill-health in welders is well documented but without a clear indication of exposures responsible.

Methods: In a Canadian cohort study of welders and electrical workers, we collected self-reports of asthma/wheeze and rhinitis at each 6-monthly contact for up to 5 years. Physician diagnoses of asthma and chronic obstructive pulmonary disease (COPD/bronchitis) were extracted from the Alberta administrative health database (AHDB).

Canadian Patients With Axial Spondyloarthritis Require Almost a Decade To Be Diagnosed Leading to Severe Functional Limitation. Results From the International Map of Axial Spondyloarthritis (IMAS).

Objective: To evaluate the sociodemographic characteristics and disease-related factors associated with diagnostic delay in Canadian patients with axial spondyloarthritis (axSpA).

Methods: Data from 542 Canadian patients who participated in the International Map of Axial Spondyloarthritis online survey were analysed. Diagnostic delay was calculated as the difference between age at diagnosis and age at onset of the first symptoms reported by participants.

Non-muscle myosin 2 can incorporate into established filaments in cells without an assembly competence domain.

Myosin 2 dynamically assembles into filaments that exert force on the actin cytoskeleton. To form filaments, myosin 2 monomers transition between folded and unfolded states. Monomer unfolding exposes an extended coiled-coil that interacts with other monomers in parallel and antiparallel fashions, enabling bipolar filament formation.

Most preoperative stress tests fail to comply with practice guideline indications and do not reduce cardiac events.

Background: There is wide variation in stress test utilization before major vascular surgery and adherence to practice guidelines is unclear. We defined rates of stress test compliance at our institution and led a quality improvement initiative to improve compliance with American Heart Association (ACC/AHA) guidelines.

Methods: We implemented a stress testing order set in the electronic medical record at one tertiary hospital.

The PCM scaffold enables RNA localization to centrosomes.

As microtubule-organizing centers, centrosomes direct assembly of the bipolar mitotic spindle required for chromosome segregation and genome stability. Centrosome activity requires the dynamic assembly of pericentriolar material (PCM), the composition and organization of which changes throughout the cell cycle. Recent studies highlight the conserved localization of several mRNAs encoded from centrosome-associated genes enriched at centrosomes, including () mRNA.