Prognostic relevance of exercise pulmonary hypertension: results of the multicentre PEX-NET Clinical Research Collaboration.

Background: Exercise pulmonary hypertension (PH) was defined by a mean pulmonary arterial pressure (mPAP)/cardiac output (CO) slope >3 mmHg·min·L between rest and exercise in the 2022 European Society of Cardiology/European Respiratory Society PH guidelines. However, large, multicentre studies on the prognostic relevance of exercise haemodynamics and its added value to resting haemodynamics are missing.

Patients And Methods: The PEX-NET (Pulmonary Haemodynamics during Exercise Network) registry enrolled patients who underwent clinically indicated right heart catheterisations both at rest and ergometer exercise from 23 PH centres worldwide.

Mediterranean Diet Pattern: Potential Impact on the Different Altered Pathways Related to Cardiovascular Risk in Advanced Chronic Kidney Disease.

Background: Cardiovascular disease (CVD) remains the most common cause of mortality in chronic kidney disease (CKD) patients. Several studies suggest that the Mediterranean diet reduces the risk of CVD due to its influence on endothelial function, inflammation, lipid profile, and blood pressure. Integrating metabolomic and proteomic analyses of CKD could provide insights into the pathways involved in uremia-induced CVD and those pathways modifiable by the Mediterranean diet.

A common framework for the development of spring water contamination early warning system in western Mediterranean karst areas: Spanish and French sites.

Karst water resources, traditionally used worldwide for drinking purposes, are highly vulnerable to contamination. Scientific-technical efforts must therefore be done to ensure sufficient water quality for human consumption. Early-Warning-Systems emerge as an effective spring scale protection strategy for real-time identification of contamination episodes at drinking water capture points.

Ionic Bent-Core Pillar[]arenes: From Liquid Crystals to Nanoaggregates and Functional Applications.

Herein, we report the first examples of supramolecular systems from bent-core-based pillar[]arenes through ionic bonds. These ionic materials have been prepared by the interaction of an amino-ended pillar[5]arene (P5N10) and three different carboxylic acids, including bent-core moieties. The bent-core units are based on ester, biphenyl, and azobenzene structures bearing two different flexible spacers between the carboxyl group and the central bent-core aromatic units.

Epidemiology of supplemental oxygen in patients with pulmonary hypertension.

Background And Objective: Patients with pulmonary hypertension (PH) may present with hypoxaemia at rest or during daily activities. There is no epidemiological data on the prescription of long-term oxygen therapy (LTOT) in patients with PH. The study sought to analyse the prevalence and incidence of LTOT prescription among patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) in Spain and to determine predictors for this prescription.