Publications by authors named "J R Asplin"
Article Synopsis
- - Hypophosphatasia (HPP) is a rare genetic condition that leads to insufficient bone mineralization and results in symptoms like low alkaline phosphatase levels and high urinary pyrophosphate excretion.
- - Nephrocalcinosis, often linked to HPP, arises from high calcium and phosphate levels but the exact nature of the resulting calcifications is unclear.
- - A 12-year-old boy was newly diagnosed with HPP after a magnesium pyrophosphate urinary stone was found; researchers recommend including infrared spectra of pyrophosphate salts in stone analysis labs for better identification of such rare stones.
Rationale & Objective: Data supporting the efficacy of preventive pharmacological therapy (PPT) to reduce urolithiasis recurrence are based on clinical trials with composite outcomes that incorporate imaging findings and have uncertain clinical significance. This study evaluated whether the use of PPT leads to fewer symptomatic stone events.
Study Design: Retrospective cohort study.
Background/aims: Hypercalciuria is the most common identifiable risk factor predisposing to CaOx stone formation. Increased oral magnesium intake may lead to decreased CaOx stone formation by binding intestinal Ox leading to decreased absorption and/or binding urinary Ox to decrease urinary supersaturation. This study assessed the effect of oral magnesium on 24-h urine ion excretion, supersaturation, and kidney stone formation in a genetic hypercalciuric stone-forming (GHS) rat model of human idiopathic hypercalciuria.
View Article and Find Full Text PDFPurpose: The consumption of alkaline water, water with an average pH of 8 to 10, has been steadily increasing globally as proponents claim it to be a healthier alternative to regular water. Urinary alkalinization therapy is frequently prescribed in patients with uric acid and cystine urolithiasis, and as such we analyzed commercially available alkaline waters to assess their potential to increase urinary pH.
Materials And Methods: Five commercially available alkaline water brands (Essentia, Smart Water Alkaline, Great Value Hydrate Alkaline Water, Body Armor SportWater, and Perfect Hydration) underwent anion chromatography and direct chemical measurements to determine the mineral contents of each product.