Publications by authors named "J Quiroz"
The association between adverse childhood experiences and adult cardiac function in the UK Biobank.
Eur Heart J Imaging Methods Pract
July 2024
Aims: The importance of early life factors in determining health in later adulthood is increasingly recognized. This study evaluated the association of adverse childhood experiences (ACEs) with cardiovascular magnetic resonance (CMR) phenotypes.
Methods And Results: UK Biobank participants who had completed CMR and the self-reported questionnaire on traumatic childhood experiences were included.
Background: The identification of predictors of treatment response is crucial for improving treatment outcome for children with anxiety disorders. Machine learning methods provide opportunities to identify combinations of factors that contribute to risk prediction models.
Methods: A machine learning approach was applied to predict anxiety disorder remission in a large sample of 2114 anxious youth (5-18 years).
Article Synopsis
- The study investigates neuromuscular junction (NMJ) function in patients with Charcot-Marie Tooth (CMT) disease and explores the potential for improving muscle strength through ClC-1 channel inhibition.
- Results showed significant NMJ abnormalities in CMT patients, such as increased jitter and blocking, which correlated with weaker muscle performance and endurance.
- Preclinical experiments indicated that a new drug, NMD670, improved muscle strength and endurance in CMT mice, suggesting that targeting NMJ dysfunction might offer a new therapeutic approach for CMT patients.
NMD670 is a first-in-class inhibitor of skeletal muscle-specific chloride channel ClC-1, developed to improve muscle weakness and fatigue in neuromuscular diseases. Preclinical studies show that ClC-1 inhibition enhances muscle excitability, improving muscle contractility and strength. We describe the first-in-human, randomized, double-blind, placebo-controlled study, which evaluated the safety, pharmacokinetics, and pharmacodynamics of single and multiple doses of NMD670 in healthy male and female subjects.
View Article and Find Full Text PDFObjective: This study aims to provide rapid and up-to-date evidence on the effectiveness of Health at Every Size (HAES) interventions compared to controls or other conventional approaches in individuals with overweight or obesity, with the goal of developing more effective and body-diverse respectful strategies.
Methods: A review of literature was carried out using the following databases: PubMed, Scopus, Embase, Web of Science, and SciELO. Research articles were selected based on predefined inclusion and exclusion criteria.