Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover trial.

Background: Guidelines recognized dual combination in initial antihypertensive therapy. Studies found that low-dose quadruple combination were superior to monotherapy. However, whether low-dose quadruple therapy is better than dual combination is unknown.

Screening and Preparation of Nanobodies for SIGLEC-15 Detection.

As an important member of the Siglec family, SIGLEC-15 plays an important role in osteoclast differentiation, bone remodeling, and tumor immune evasion. In the tumor microenvironment, SIGLEC-15 functions independently of the B7-H1/PD-1 pathway. In this study, the SIGLEC-15 fusion protein (SIGLEC-15-Fc) was successfully expressed and purified using a eukaryotic expression system.

Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining.

The benefits of exercise for metabolic health occur in a dose-dependent manner. However, the adverse effects of overtraining and their underlying mechanisms remain unclear. Here, we show that overtraining induces hepatic fibrosis.

Simplified self-supervised learning for hybrid propagation graph-based recommendation.

Recent progress in Graph Convolutional Networks (GCNs) has facilitated their extensive application in recommendation, yielding notable performance gains. Nevertheless, existing GCN-based recommendation approaches are confronted with several challenges: (1) how to effectively leverage multi-order graph connectivity to derive meaningful node embeddings; (2) faced with sparse raw data, how to augment supervision signals without relying on auxiliary information; (3) given that GCNs necessitate the aggregation of neighborhood nodes, and the sparsity of these nodes can exacerbate the impact of noise data, how to mitigate the noise problem inherent in the raw data. For tackling aforementioned challenges, we devise a new hybrid propagation GCN-based method named S3HGN, incorporating a simplified self-supervised learning paradigm for recommendation.

Characterization and application of fluorescent hydrogel films with superior mechanical properties in detecting iron(Ⅲ) ions and ferroptosis in oral cancer.

A one-step hydrothermal method was applied to prepare carbon dots (CDs) with superior fluorescence properties using chitosan as a carbon source. The as-prepared carbon dots were then grafted onto a sodium alginate-gelatin hydrogel film to form a fluorescent hydrogel film (FHGF), emitting at 450 nm under excitation of 350 nm light. In comparison to the CDs, the fluorescence intensity of this film was maintained over 90.