Future Proofing Study: a cluster randomised controlled trial evaluating the effectiveness of a universal school-based cognitive-behavioural programme for adolescent depression.

Background: Psychological prevention programmes delivered in schools may reduce symptoms of depression. However, high-quality, large-scale trials are lacking.

Objective: The aim was to examine whether a digital cognitive-behavioural programme ('SPARX'), delivered at scale in schools, would reduce depressive symptoms 12 months later.

The relationships between depression, inflammation and self-reported disease activity in IBD and their impact on healthcare usage.

Background: Depression is common in people living with Inflammatory Bowel Disease (IBD). Depression rates increase with active disease and are linked to poorer clinical outcomes. Previous studies investigating the relationship between contemporaneous IBD disease activity and depression are often poorly controlled, use small samples and/or rely on self-reported measures of disease activity.

Electron exchange capacity of dissolved natural organic matter: further method development and interpretation using square wave voltammetry in dimethyl sulfoxide.

Most measurements of the electron exchange capacity (EEC) of natural organic matter (NOM) have been done in water using mediated chronoamperometry (MCA), which gives precise results that are believed to be representative of the samples' current redox condition, but the broader significance of these EECs is less clear. In a recent study, we described a novel but complementary electrochemical approach to quantify EECs of 10 pyrogenic dissolved organic matter (pyDOM) and 6 standard/reference natural organic matter (NOM) materials without mediation using square-wave voltammetry (SWV) in dimethyl sulfoxide (DMSO). Comparison of the results obtained by MCA and SWV showed that SWV in DMSO gave larger EECs than MCA, by several-fold for NOM and 1-2 orders of magnitude for pyDOM.

Underlying Disease in Atypical Retinopathy of Prematurity.

Background And Objective: Retinopathy of prematurity (ROP), familial exudative vitreoretinopathy (FEVR), and telomere biology disorders (TBD) are classified as distinct diseases. However, emerging genetic research and evidence on multimodal imaging suggest a spectrum along which ROP may overlap with FEVR or TBD.

Design: Retrospective case series.

Tackling pressure fluctuations in ultra-HPLC to robustly resolve and analyze polar metabolites.

The success of modern metabolomics analysis depends on the separation of metabolites in complex samples using methods such as LC and mass spectrometry. Herein, we present a protocol for resolving a broad range of polar metabolites, based on hydrophilic interaction LC with a zwitterionic-bonded phase (HILICz). In optimizing this protocol, we encountered pressure fluctuations, a widespread problem that impacts metabolite analysis, restricts batch sizes, and imposes instrument downtime, ultimately incurring substantial time and financial expense.