Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy.

Molecular characterization of tumors is essential to identify predictive biomarkers that inform treatment decisions and improve precision immunotherapy development and administration. However, challenges such as the heterogeneity of tumors and patient responses, limited efficacy of current biomarkers, and the predominant reliance on single-omics data, have hindered advances in accurately predicting treatment outcomes. Standard therapy generally applies a "one size fits all" approach, which not only provides ineffective or limited responses, but also an increased risk of off-target toxicities and acceleration of resistance mechanisms or adverse effects.

Influence of π-π interactions on organic photocatalytic materials and their performance.

Currently, organic photocatalyst-based photocatalysis has garnered significant attention as an environmentally friendly and sustainable reaction system due to the preferable structural flexibility and adjustable optoelectronic features of organic photocatalysts. In addition, π-π interactions, as one of the common non-bonded interactions, play an important role in the structure and property adjustments of organic photocatalysts due to their unique advantages in modulating the electronic structure, facilitating charge migration, and influencing interfacial reactions. However, studies summarizing the relationship between the π-π interactions of organic photocatalysts and their photocatalytic performance are still rare.

Associations between CAG repeat size, brain and spinal cord volume loss, and motor symptoms in spinocerebellar ataxia type 3: a cohort study.

Background: Spinocerebellar ataxia type 3 (SCA3) is a hereditary disease caused by abnormally expanded CAG repeats in the ATXN3 gene. The study aimed to identify potential biomarkers for assessing therapeutic efficacy by investigating the associations between expanded CAG repeat size, brain and spinal cord volume loss, and motor functions in patients with SCA3.

Methods: In this prospective, cross-observational study, we analyzed 3D T1-weighted MRIs from 92 patients with SCA3 and 42 healthy controls using voxel-based morphometry and region of interest approaches.