Metabolic profiling of polysaccharides from Leccinum crocipodium (Letellier.) Watliag stem fermented by Bacteroides thetaiotaomicron and their immunomodulatory effects.

Leccinum crocipodium (Letellier.) Watliag has attracted increasing attention for their biological activity. In this study, the active polysaccharide components (LCSP11 and LCSP22) extracted from the stem of L.

Circadian rhythm modulation in heart rate variability as potential biomarkers for major depressive disorder: A machine learning approach.

Major depressive disorder (MDD) is associated with reduced heart rate variability (HRV), but its link to circadian rhythm modulation (CRM) of HRV is unclear. Given that depression disrupts circadian rhythms, assessing HRV fluctuations may better capture the CRM and the related autonomic nervous system (ANS) alterations, potentially enhancing our understanding of the pathophysiological mechanisms of MDD. This study aimed to explore the relationship between CRM of HRV and MDD, and to identify potential biomarkers for MDD using machine learning (ML).

Transcriptomic and metabolic profiling reveals the effects of long-term microwave exposure on testicular tissue.

The effect of electromagnetic exposure on health is becoming increasingly important as it affects many aspects of human life and health. However, the effects in environmental electromagnetic fields on the male reproductive system were still controversial, and the impacts of long-term microwave exposure on testicular tissue remain poorly defined. This study exposed rats to 30 mW/cm of microwave radiation (2.

Measurement of Very-High-Energy Diffuse Gamma-Ray Emissions from the Galactic Plane with LHAASO-WCDA.

The diffuse Galactic gamma-ray emission is a very important tool used to study the propagation and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of the diffuse emission from the Galactic plane-covering Galactic longitudes from 15° to 235° and latitudes from -5° to +5°, in an energy range of 1 to 25 TeV-made with the Water Cherenkov Detector Array (WCDA) of the Large High Altitude Air Shower Observatory. After the sky regions of known sources are masked, the diffuse emission is detected with 24.

The kinase CPK5 phosphorylates MICRORCHIDIA1 to promote broad-spectrum disease resistance.

In Arabidopsis (Arabidopsis thaliana), MICRORCHIDIA 1 (MORC1), a member of the MORC family of evolutionarily conserved GHKL-type ATPases, plays important roles in multiple layers of plant immunity. However, the molecular mechanism by which MORC1 regulates plant immunity remains obscure. Here, we report that the pathogen-responsive kinase CALCIUM-DEPENDENT PROTEIN KINASE 5 (CPK5) directly interacts with and phosphorylates MORC1, thereby promoting its stability and nuclear translocation.