Publications by authors named "J Pytel"
Background/aim: The role of microRNAs (miRNA) in carcinogenesis is related to their genome-regulatory function. The aim of the present study was to identify and compare miRNA expression signatures of meso- and hypopharynx squamous cell cancers in consideration of the cancer field hypothesis.
Patients And Methods: Thirteen snap-frozen biopsy series of tumors and peritumoral tissues from the meso- and hypopharynx were analyzed regarding their miRNA expression with quantitative real-time polymerase chain reaction (qRT-PCR).
Retrospective analysis of tympanoplasty in children with cleft palate: a 24-year experience. II. Cholesteatomatous cases.
Int J Pediatr Otorhinolaryngol
May 2015
Background: Contradictory experience has been published on the outcomes of ear surgery in patients with cleft palate.
Objectives: The authors of this study investigated whether there were differences in the short- and long-term outcomes of tympanoplasty performed due to cholesteatoma in children with or without cleft palate.
Setting: Tertiary care medical centre.
Article Synopsis
- * Researchers conducted their analysis on 13 frozen biopsy samples, examining both tumor tissue and nearby apparently normal tissues taken at different distances from the tumor.
- * Findings revealed specific microRNAs, like miR-221 and miR-21, are overexpressed in respective cancer types; this differential expression could be leveraged for early cancer detection and evaluating cancer risks.
Background: Contradictory data have been published on the outcomes of ear surgeries in cleft patients.
Objectives: To investigate whether there are differences in the short and long term outcomes of tympanoplasty performed due to childhood chronic mesotympanic otitis media in patients without and with cleft palate.
Setting: Tertiary care pediatric medical centre.