Vertically Grown Bioinspired Diphenylalanine Nanowire-Coated Fabric for Oil-Water Separation.

Due to the pervasive use of oil for energy and other industrial applications, solutions to oil-water separation have received a great deal of attention lately to address the environmental damage of oil spills and groundwater contamination. However, many of these separation methods are materially expensive and environmentally hazardous, require elaborate fabrication, or rely on large amounts of energy to function. Herein, we provide an effective low-cost method for oil-water separation based on the hydrophobicity induced by self-assembled bioinspired diphenylalanine peptide nanowires grown on polyester fabric.

A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion.

Oligomeric species populated during α-synuclein aggregation are considered key drivers of neurodegeneration in Parkinson's disease. However, the development of oligomer-targeting therapeutics is constrained by our limited knowledge of their structure and the molecular determinants driving their conversion to fibrils. Phenol-soluble modulin α3 (PSMα3) is a nanomolar peptide binder of α-synuclein oligomers that inhibits aggregation by blocking oligomer-to-fibril conversion.

Clinical, Pathological and Virological Outcomes of Tissue-Homogenate-Derived and Cell-Adapted Strains of Porcine Epidemic Diarrhea Virus (PEDV) in a Neonatal Pig Model.

Porcine epidemic diarrhea virus (PEDV) is characterized by diarrhea, vomiting, dehydration, and high mortality rates in neonatal piglets. Two distinct genogroups, S-INDEL (G1a, G1b) and non-S INDEL (G2a, G2b, and G2c), circulate worldwide and are characterized by varying degrees of virulence. Here, we compared the early pathogenesis of a PEDV S-INDEL strain obtained from intestine homogenate (CALAF-HOMOG) or adapted to cell culture by 22 passages (CALAF-ADAP) and a virulent non-S INDEL strain (PEDV-USA) in newborn piglets.