Publications by authors named "J Protze"
3,5,3'-Triiodothyroacetic acid (TRIAC) is a T-receptor agonist pharmacologically used in patients to mitigate T resistance. It is additionally explored to treat some symptoms of patients with inactivating mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8, ). MCT8 is expressed along the blood-brain barrier, on neurons, astrocytes, and oligodendrocytes.
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- Herpesviruses, known for their large and complex structure, challenge researchers in characterizing them due to their size and fragile nature.
- Using advanced techniques like crosslinking mass spectrometry, researchers mapped out the spatial organization of viral proteins within human cytomegalovirus, identifying 32 viral proteins across four distinct layers.
- The study revealed the important role of viral protein UL32 in connecting various layers and regulating host protein interactions, specifically affecting the binding dynamics between UL32 and 14-3-3 proteins, which is crucial for successful virus formation.
Huntington's disease is a neurodegenerative disease caused by an expanded polyQ stretch within Huntingtin (HTT) that renders the protein aggregation-prone, ultimately resulting in the formation of amyloid fibrils. A trimeric chaperone complex composed of Hsc70, DNAJB1 and Apg2 can suppress and reverse the aggregation of HTTExon1Q. DNAJB1 is the rate-limiting chaperone and we have here identified and characterized the binding interface between DNAJB1 and HTTExon1Q.
View Article and Find Full Text PDFTc toxins deliver toxic enzymes into host cells by a unique injection mechanism. One of these enzymes is the actin ADP-ribosyltransferase TccC3, whose activity leads to the clustering of the cellular cytoskeleton and ultimately cell death. Here, we show in atomic detail how TccC3 modifies actin.
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