Publications by authors named "J Povar Marco"
The charge transfer (CT) reactions in nucleic acids are crucial for genome damage and repair and nanoelectronics using DNA as a molecular conductor. Previous experimental and theoretical works underlined the significance of nucleic acid structural dynamics on CT kinetics, requiring models that incorporate the dynamics of the nucleic acid, solvents, and counterions. Here, we investigated hole transfer kinetics in poly adenine single and double strands at various temperatures and the rate enhancement due to adenine-to-7-deazaadenine mutation by means of a QM/MM approach.
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- Family members of individuals with Borderline Personality Disorder (BPD) often struggle with mental health issues like depression and anxiety, leading to a significant burden.
- Family Connections (FC) is an effective program designed for these relatives, and this study aimed to compare its impact against standard treatment in a Spanish population through a randomized clinical trial.
- Although no major statistical differences were found between FC and the usual treatment, results indicated that FC led to improved outcomes in burden, stress, and quality of life for both family members and patients, highlighting the value of involving families in treatment for psychological disorders.
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- The Neotropical realm is a highly biodiverse region with significant public health risks due to zoonoses, particularly zoonotic leishmaniasis caused by Leishmania (Viannia) braziliensis.
- This study represents the first genome-wide analysis of 257 Leishmania isolates across Latin America, revealing extensive genetic variability among populations associated with different environments.
- Two major parasite groups were identified, one linked to the Amazon and the other to the Atlantic Forest, each showing distinct genetic profiles and eco-epidemiological characteristics.
The world is lagging in achieving the 2030 Agenda's 17 Sustainable Development Goals (SDGs), emphasizing social, economic, and environmental dimensions. Meeting one target may either help or hinder meeting another, but the high number of potential interactions complicates the evaluation of synergies and trade-offs. Here, we focus on the water-energy-food nexus to assess how the knowledge of SDG interlinkages has been operationalized to inform policymaking.
View Article and Find Full Text PDFIn the chronic phase of Chagas disease (CCD), diagnosis relies on detecting specific IgG antibodies due to the low or absent presence of the parasite in human blood. However, the performance of current serological tests is highly variable, lacking a "" assay with 100% sensitivity and specificity, which challenges the exploration of new biomarkers. In the present study, we evaluated the diagnostic accuracy of an optimized ELISA using the predicted immunogenic domains (called TcD3 and TcD6) of Tc323, a protein highly conserved among strains but absent in other clinically significant parasites such as .
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