Publications by authors named "J Poulton"
Article Synopsis
- Inclusion body myositis (IBM) is a type of muscle disease that usually starts later in life and causes weakness in specific muscles, especially in the hands and knees.
- Scientists don't know exactly why it happens or how to treat it effectively yet, but they found some changes in muscle cells that could help in figuring it out.
- The review talks about the latest findings on diagnosing IBM, the role of proteins in the disease, current treatments, and new ideas for future therapies that might help people who have IBM.
Article Synopsis
- Mitochondrial DNA depletion syndrome (MDS) is a condition where patients struggle to make enough energy because they lack proper mitochondrial DNA (mtDNA).
- There’s no cure for MDS yet, but scientists are testing new treatments with special nucleoside supplements to see if they can help boost mtDNA levels in cells.
- In experiments, one specific combination of nucleosides called ATGC worked really well at helping increase mtDNA in certain cells after being depleted, although higher doses caused some toxic effects.
Leigh syndrome spectrum (LSS) is a primary mitochondrial disorder defined neuropathologically by a subacute necrotizing encephalomyelopathy and characterized by bilateral basal ganglia and/or brainstem lesions. LSS is associated with variants in several mitochondrial DNA genes and more than 100 nuclear genes, most often related to mitochondrial complex I (CI) dysfunction. Rarely, LSS has been reported in association with primary Leber hereditary optic neuropathy (LHON) variants of the mitochondrial DNA, coding for CI subunits (m.
View Article and Find Full Text PDFEpitope mapping provides critical insight into antibody-antigen interactions. Epitope mapping of autoantibodies from patients with autoimmune diseases can help elucidate disease immunogenesis and guide the development of antigen-specific therapies. Similarly, epitope mapping of commercial antibodies targeting known autoantigens enables the use of those antibodies to test specific hypotheses.
View Article and Find Full Text PDFIntroduction: Podocyte slit diaphragms are an important component of the glomerular filtration barrier. Podocyte injury frequently includes defects in slit diaphragms, and various mechanisms for these defects have been described, including altered endocytic trafficking of slit diaphragm proteins or oxidative stress. However, the potential relationship between endocytosis and oxidative stress in the context of slit diaphragm integrity has not been extensively considered.
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