Publications by authors named "J Poulter"
Article Synopsis
- The study focuses on the detection of ASC aggregates, which are important for inflammasome assembly, particularly the NLRP3 inflammasome, after pyroptotic cell death.
- Researchers developed a method using human monocytes, macrophages, and ASC reporter cells to identify ASC/NLRP3-positive events via flow cytometry.
- Results showed increased ASC/NLRP3 specks in the sera of patients with inflammatory conditions, indicating that FACS is a reliable detection method with potential diagnostic uses in autoinflammatory diseases.
Article Synopsis
- Adult-onset Still's disease (AOSD) is a complex autoinflammatory disorder with unclear causes, and this study aims to explore its genetic background and potential treatment targets.
- Researchers analyzed 60 AOSD patients using advanced genetic techniques and blood profiling to uncover rare genetic variants and inflammation markers.
- Results indicated a higher frequency of certain genetic variants and significant elevation of specific cytokines and immune system markers in AOSD patients, suggesting a complicated genetic landscape that could lead to new approaches in treatment.
Photodynamic Therapy (PDT) is an emerging method to treat colorectal cancers (CRC). Hypericin (HYP) is an effective mediator of PDT and the ABCG2 inhibitor, Febuxostat (FBX) could augment PDT. HT29 and HEK293 cells showed light dependant cytotoxic response to PDT in both 2D and 3D cell models.
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- Plexins are important receptors associated with semaphorin signaling, involved in essential cellular interactions during both development and adulthood, with only some variants linked to genetic diseases so far.
- A study examined eight individuals from six families with a rare recessive condition characterized by amelogenesis imperfecta (AI), sensorineural hearing loss (SNHL), and varying levels of intellectual disability, using genetic sequencing and variant analysis.
- The research identified pathogenic biallelic variants in the plexin B2 gene, linked to a new autosomal recessive syndrome that features AI and SNHL, along with potential additional symptoms like intellectual disability and developmental abnormalities.
Background: Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumors almost always fatally recur.
Results: Using RNA sequencing data from 107 pairs of pre- and post-standard treatment locally recurrent IDHwt GBM tumors, we identify two responder subtypes based on longitudinal changes in gene expression.