Publications by authors named "J Popovic"
The neutrophil marker CD177 (NB1, HNA-2a) is expressed by 0-100% of circulating neutrophils in any given donor, dividing neutrophils into two distinct subpopulations (CD177pos and CD177neg). High proportions of CD177pos blood neutrophils have been linked to both systemic infections and a range of inflammatory pathologies, but whether this is a cause or a consequence of disease is not known. Many conditions displaying elevated CD177pos neutrophil proportions are also accompanied by the presence of circulating low-density granulocytes (LDGs).
View Article and Find Full Text PDFThe structural and electronic features of the stimuli-responsive supramolecular inter-ionic charge-transfer material containing electron accepting -benzylyridinium-4-oxime cation (BPA4) and electron donating hexacyanoferrate (II) are reported. The study of reversible stimuli-induced transformation between hydrated reddish-brown (BPA4)[Fe(CN)]·10HO and anhydrous blue (BPA4)[Fe(CN)] revealed the origin of observed hydrochromic behavior. The comparison of the crystal structures of decahydrate and anhydrous phase showed that subsequent exclusion/inclusion of lattice water molecules induces structural relocation of one BPA4 that alter the donor-to-acceptor charge-transfer states, resulting in chromotropism seen as reversible reddish-brown to blue color changes.
View Article and Find Full Text PDFAngiotensin I converting enzyme (ACE1) maintains blood pressure homeostasis by converting angiotensin I into angiotensin II in the renin-angiotensin system (RAS). ACE1 is expressed in the brain, where an intrinsic RAS regulates complex cognitive functions including learning and memory. ACE1 has been implicated in neurodegenerative disorders including Alzheimer's disease and Parkinson's disease, but the mechanisms remain incompletely understood.
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- Oxidative stress, caused by an imbalance between antioxidants and reactive oxygen species, can lead to serious oral diseases; the study aimed to examine the effects of removable dentures on oxidative stress markers.
- Involving 40 participants aged 28-78, saliva samples were taken before and after denture placement, revealing peak reactive oxygen species production on the seventh day and a subsequent decline in antioxidant defenses.
- The NF-κB p65 subunit expression increased after seven days, indicating redox imbalance and potential inflammation in oral tissues, suggesting that dentures and their materials may contribute to oral diseases, warranting further research.
Purpose: There is increasing recognition of the importance of transparency and reproducibility in scientific research. This study aimed to quantify the extent to which programming code is publicly shared in pharmacoepidemiology, and to develop a set of recommendations on this topic.
Methods: We conducted a literature review identifying all studies published in Pharmacoepidemiology and Drug Safety (PDS) between 2017 and 2022.