Publications by authors named "J Poposki"
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by type 2 (T2) inflammation. Recent studies, including our own, suggest that neutrophils are also elevated in T2 nasal polyps (NP) and that elevated neutrophils display an activated phenotype. However, the actual roles of neutrophils in NP pathogenesis in T2 CRSwNP are still largely unclear.
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- * Researchers found that NP B cells expressing the extrafollicular marker EBI2 had a higher propensity for autoantibody production and that NP ASCs were more common than those in tonsils.
- * Analysis showed significant differences in the composition and molecular characteristics of B cells, indicating that NP EBI2+ ASCs produce more total and anti-dsDNA IgG and exhibit traits of mature plasma cells.
Article Synopsis
- Chronic rhinosinusitis with nasal polyps (CRSwNP) involves complex inflammation, and the specific functions of eosinophils in this condition are not well understood.
- Researchers used single-cell RNA sequencing to analyze eosinophils in nasal polyp tissue from patients with CRSwNP, comparing them to control samples.
- The study identified a diverse range of eosinophil subtypes in nasal polyps, with certain genes related to inflammation and cell growth being significantly upregulated, suggesting their key role in CRSwNP pathology.
Background: Oncostatin M (OSM) may promote type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) by inducing thymic stromal lymphopoietin (TSLP).
Objective: We sought to study the impact of OSM on TSLP synthesis and release from nasal epithelial cells (NECs).
Methods: OSM receptors, IL-4 receptors (IL-4R), and TSLP were evaluated in mucosal tissue and primary NECs from patients with CRSwNP by quantitative PCR and immunofluorescence.
Background: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is well characterized by type 2 (T2) inflammation characterized by eosinophilia in Western countries. However, the presence and roles of neutrophils in T2 CRSwNP are poorly understood.
Objective: We sought to clarify accumulation and inflammatory roles of neutrophils in CRSwNP in a Western population.