ENNGene: an Easy Neural Network model building tool for Genomics.

Background: The recent big data revolution in Genomics, coupled with the emergence of Deep Learning as a set of powerful machine learning methods, has shifted the standard practices of machine learning for Genomics. Even though Deep Learning methods such as Convolutional Neural Networks (CNNs) and Recurrent Neural Networks (RNNs) are becoming widespread in Genomics, developing and training such models is outside the ability of most researchers in the field.

Results: Here we present ENNGene-Easy Neural Network model building tool for Genomics.

Silver Diamine Fluoride and Progression of Incipient Approximal Caries in Permanent Teeth: A Retrospective Study.

The purpose of this study was to evaluate the progression of incipient approximal caries lesions in permanent teeth of children and adolescents with and without silver diamine fluoride (SDF) application. A retrospective analysis of dental records and radiographs was performed. Baseline and follow-up bitewing radiographs were evaluated and scored using International Caries Classification and Management System (ICCMS) criteria to assess lesion progression.

A Short Note about the Impact Action of a Water Jet Stabilized by a Coaxial Air Stream in the Air and Underwater.

A new original method, applying a coaxial protective airflow, was tested aiming to improve the pure water jet efficiency in surface layer removal or medium hard materials cutting or blasting. The dual action of the air flow is expected: the air co-flowing the water jet with approximately the same velocity should prevent the central jet from breaking up into tiny droplets in the near field, and simultaneously, it should support jet decomposition into big parts with enough destructive potential in the far-field. A brief survey of the relevant literature dealing with the water jet instability is presented, introducing four recognized breakup regimes.

PENGUINN: Precise Exploration of Nuclear G-Quadruplexes Using Interpretable Neural Networks.

G-quadruplexes (G4s) are a class of stable structural nucleic acid secondary structures that are known to play a role in a wide spectrum of genomic functions, such as DNA replication and transcription. The classical understanding of G4 structure points to four variable length guanine strands joined by variable length nucleotide stretches. Experiments using G4 immunoprecipitation and sequencing experiments have produced a high number of highly probable G4 forming genomic sequences.

Dissolution rate-limited absorption and complete bioavailability of roquinimex in man.

In order to investigate the bioavailability and the rate-limiting step of the absorption of roquinimex, an oral solution and a tablet formulation (Linomide(R)) were given to healthy volunteers. The study was conducted as a randomized three-period crossover study in seven male and seven female healthy volunteers. The subjects received an intravenous infusion, an oral solution and an oral tablet formulation, each of 5 mg (about 0.