Publications by authors named "J Pitha"
Introduction: The main goal of this study was to describe the Czech population of patients with MG in terms of demographics, disease characteristics, management approaches, and treatment trends.
Methods: We selected all patients, both incident and prevalent, who were enrolled in the Czech MyReg registry between August 24, 2015 and November 19, 2021. For the descriptive analysis, all patients enrolled in the registry, regardless of their date of diagnosis or date of enrolment, were included.
Background: Venotonics are a class of therapeutically active molecules that have vaso-protective effects. They are used to alleviate venous diseases and disorders, particularly venous insufficiency. We compared the composition of prescription versus over-the-counter (OTC) venotonics using high-performance liquid chromatography with UV detection (HPLC-DAD) and simulating their digestion using a static digestive model.
View Article and Find Full Text PDFArticle Synopsis
- The study examines the complex associations between cardiovascular risk factors and vascular health in individuals with type 1 diabetes (T1D), highlighting differences when compared to type 2 diabetes.
- It involved a cross-sectional analysis of various vascular parameters in T1D patients under 65 years old, assessing factors like ankle-brachial index (ABI) and kidney health indicators.
- Results indicated that pulse pressure significantly correlated with adverse vascular outcomes, while lipid factors mostly impacted renal health, with variations based on sex and genetic traits, specifically regarding the Cx37 gene polymorphism.
Background: The highest mortality and morbidity worldwide is associated with atherosclerotic cardiovascular disease (ASCVD), which has in background both environmental and genetic risk factors. Apolipoprotein L1 (APOL1) variability influences the risk of ASCVD in Africans, but little is known about the APOL1 and ASCVD in other ethnic groups.
Methods: To investigate the role of APOL1 and ASCVD, we have genotyped four (rs13056427, rs136147, rs10854688 and rs9610473) APOL1 polymorphisms in a group of 1541 male patients with acute coronary syndrome (ACS) and 1338 male controls.
Background: Data on the clinical significance of iron deficiency (ID) in patients with myocardial infarction (MI) are conflicting. This may be related to the use of various ID criteria. We aimed to compare the association of different ID criteria with all-cause mortality after MI.
View Article and Find Full Text PDF