Publications by authors named "J Pino"
Diesel exhaust particles (DEPs) are atmospheric pollutants associated with adverse health effects. In response to their impact, natural gas (NG) has emerged as a promising alternative fuel due to its cleaner combustion. Although the cytotoxicity and genotoxicity of DEPs from diesel or NG engines have been extensively studied, the impact of dual natural gas-diesel systems remains unexplored.
View Article and Find Full Text PDFIschaemic stroke is a leading cause of death and disability. Circulating extracellular vesicles (EVs) post-stroke may help brain endothelial cells (BECs) counter ischaemic injury. However data on how EVs from ischaemic stroke patients, considering injury severity, affect these cells are limited.
View Article and Find Full Text PDFOne regime of experimental particle-laden flow study involves ejecta microjets-often defined as a stream of micrometer-scale particles generated through shock interaction with a non-uniform surface and generally travel above 1 km/s. In order to capture the change in characteristics as a function of propagation time, we apply a multi-frame x-ray radiography platform to observe and track the jet transport dynamics. A synchrotron x-ray source allows us to perform quantitative analyses and comparisons between the eight images captured by the imaging system.
View Article and Find Full Text PDFArticle Synopsis
- - PFOS, an industrial chemical linked to cognitive decline, negatively affects learning and memory by disrupting key brain functions, particularly in cholinergic neurons that are vital for cognitive health.
- - Research using SN56 cholinergic cells revealed that PFOS decreases thyroid receptor activity, disrupts cholinergic and glutamatergic transmission, and impacts the levels of essential neurotransmitters through various biochemical changes.
- - The study suggests that reducing thyroid hormone activity due to PFOS exposure contributes to neurodegeneration, but supplementing with thyroid hormone (T3) can partially restore normal function, highlighting potential therapeutic approaches.
Article Synopsis
- - This study examines how inflammation in chondrogenic cells affects rat and mouse glial cell lines, particularly focusing on the role of nitric oxide (NO) in their communication.
- - Researchers used a transwell system to coculture inflamed ATDC5 cells with GL261 or C6 glioma cells, measuring cell viability and gene expression changes.
- - Findings reveal that NO from chondrocytes enhances inflammatory signals in glial cells via specific signaling pathways (ERK1/2 and AKT), suggesting a link between cartilage inflammation and neuroinflammation in conditions like osteoarthritis.