Publications by authors named "J Pinilla-Ibarz"
Transcription factors control genes to maintain normal hemopoiesis, and dysregulation of some factors can lead to acute lymphoblastic leukemia (ALL). Mycoviruses are known to alter the genetics of their fungal host. The present study evaluates the effects of the products of a mycovirus-containing (MCAF), isolated from the home of a patient with ALL, on certain transcription factors of normal and ALL cell lines.
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- * Patients reported improvements in physical functioning and fatigue within a year post-treatment, but indicators of pain, anxiety, and depression remained stable or worsened in those with active disease.
- * While overall toxicity decreased for the first 180 days, it increased again by day 360; prior therapies influenced worsening pain and anxiety in patients with extensive treatment histories.
Article Synopsis
- Preclinical studies have shown that in vitro-differentiated Th17 cells can be effective in solid tumors, but their potential in enhancing adoptive cell therapy (ACT) for hematological cancers like chronic lymphocytic leukemia (CLL) is not yet explored.
- CLL, a type of B-cell cancer, faces issues with resistance to targeted therapies, and existing T-cell treatments like CAR T cells have seen limited success due to T-cell dysfunction and immunosuppressive responses.
- This research highlights the successful polarization of CD4 T cells into a Th17 phenotype from a CLL mouse model, demonstrating improved memory properties and persistence in treating leukemia, marking a significant step towards enhancing ACT efficacy in CLL with Th17 CAR T