[Genetic counseling and successful pregnancy in patient with Wilson disease].

The principles of genetic counselling are summarized in a female with Wilson's disease. Pregnancy after appropriate treatment during gestation had a successful outcome: a healthy boy.

Attempts with lipanthyl to improve lipid metabolism during the adaptation period of women taking oral contraceptives.

In the course of a 6-month comparative prospective clinical trial the parameters of fat metabolism in women taking first oral contraceptives of different hormone balances and contents were examined. It has been observed that the different tablets increase within the physiological limits the levels of total cholesterol and triglyceride as well as LDL-cholesterol and--except for the biphasic tablet--they decrease HDL fraction. By administering minimum doses of fenofibrate the increase and changes in fat metabolism may be prevented and the eventual unwanted effects of the adaptation period moderated.

[Role of cerclage in the prevention of abortion and premature labor].

In the course of the analysis of the results of 175 cerclage-operations carried out during the last 5 years, the authors intended to answer the question: whether the operation is reasonable on the basis of a prophylactic indication. As indication of this kind has been considered for example the following: when in the case-history of the patient one or more spontaneous abortions have occured after the third month of gravidity--with insufficient symptoms, when the mother's birth was a full-term confinement after cerclage-operation, finally, when the insufficiency of the cervical os had been diagnosed before getting pregnant. At symptoms of incipient abortion the aim of the medical treatment was therapeutic.