Publications by authors named "J Ph Bedel"
Crowned dens syndrome is characterized by severe neck pain with stiffness of the neck, sometime febrile, due to calcification of the transverse atlas ligament. We describe the case of a 65-year-old woman referred to the emergency department with a suspicion of meningitis. Several anamnestic and clinical signs ruled out this hypothesis.
View Article and Find Full Text PDFBackground: In the phase 3 trial ARIEL3, maintenance treatment with the poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib provided clinical benefit versus placebo for patients with recurrent, platinum-sensitive ovarian cancer. Here, we evaluate the impact of age on the clinical utility of rucaparib in ARIEL3.
Methods: Patients with platinum-sensitive, recurrent ovarian carcinoma with ≥2 prior platinum-based chemotherapies who responded to their last platinum-based therapy were enrolled in ARIEL3 and randomized 2:1 to rucaparib 600 mg twice daily or placebo.
Article Synopsis
- The study evaluates the effectiveness of rucaparib, a maintenance treatment for ovarian cancer, versus a placebo using metrics like quality-adjusted progression-free survival (QA-PFS) and quality-adjusted time without symptoms or toxicity (Q-TWiST).
- Results showed that patients on rucaparib had significantly longer mean QA-PFS and Q-TWiST compared to those on placebo, especially in specific genetic cohorts like the -mutant and homologous recombination deficient (HRD) groups.
- The findings suggest rucaparib not only prolongs life without disease progression but also improves the quality of life during those periods, making it a promising option for patients with recurrent ovarian cancer.