Publications by authors named "J Peulen-Zink"
Background And Aims: The enteric nervous system (ENS), comprised of neurons and glia, regulates intestinal motility. Hirschsprung disease (HSCR) results from defects in ENS formation, yet while neuronal aspects have been extensively studied, enteric glia remain disregarded. This study aimed to explore enteric glia diversity in health and disease.
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- - Gata2 is essential for creating Haematopoietic Stem and Progenitor Cells (HSPCs) from haemogenic endothelium, and issues with Gata2 can cause blood disorders.
- - Researchers deleted a critical enhancer in zebrafish that affects gata2a expression and found that while gata2a larvae initially had normal HSPC numbers, adult gata2a fish displayed problems like edema and bone marrow failure.
- - The study highlights the importance of Gata2a regulated by the enhancer for proper embryonic development and ongoing stem cell function in adults, with potential implications for understanding GATA2-related diseases.